Fertility preservation in pre-pubertal girls with cancer: the role of ovarian tissue cryopreservation

W Hamish B Wallace, Thomas W Kelsey, Richard A Anderson

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)

Abstract

With increasing numbers of survivors of cancer in young people future fertility and ovarian function are important considerations that should be discussed before treatment commences. Some young people, by nature of the treatment they will receive, are at high risk of premature ovarian insufficiency and infertility. For them, ovarian tissue cryopreservation (OTC) is one approach to fertility preservation that remains both invasive and for young patients experimental. There are important ethical and consent issues that need to be explored and accepted before OTC can be considered established in children with cancer. In this review we have discussed a framework for patient selection which has been shown to be effective in identifying those patients at high risk of premature ovarian insufficiency (POI) and who can be offered OTC safely.
Original languageEnglish
Pages (from-to)6-12
Number of pages7
JournalFertility and Sterility
Volume105
Issue number1
Early online date7 Dec 2015
DOIs
Publication statusPublished - Jan 2016

Keywords

  • Adolescent
  • Age Factors
  • Animals
  • Child
  • Child, Preschool
  • Cryopreservation
  • Female
  • Fertility
  • Fertility Preservation
  • Humans
  • Infant
  • Infant, Newborn
  • Infertility, Female
  • Neoplasms
  • Ovary
  • Patient Selection
  • Pregnancy
  • Primary Ovarian Insufficiency
  • Risk Factors
  • Survivors
  • Treatment Outcome
  • Journal Article
  • Review

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