Fertility preservation in pre-pubertal girls with cancer: the role of ovarian tissue cryopreservation

W Hamish B Wallace; Thomas W Kelsey; Richard A Anderson

doi:10.1016/j.fertnstert.2015.11.041

Fertility preservation in pre-pubertal girls with cancer: the role of ovarian tissue cryopreservation

W Hamish B Wallace, Thomas W Kelsey, Richard A Anderson

Research output: Contribution to journal › Article › peer-review

Abstract

With increasing numbers of survivors of cancer in young people future fertility and ovarian function are important considerations that should be discussed before treatment commences. Some young people, by nature of the treatment they will receive, are at high risk of premature ovarian insufficiency and infertility. For them, ovarian tissue cryopreservation (OTC) is one approach to fertility preservation that remains both invasive and for young patients experimental. There are important ethical and consent issues that need to be explored and accepted before OTC can be considered established in children with cancer. In this review we have discussed a framework for patient selection which has been shown to be effective in identifying those patients at high risk of premature ovarian insufficiency (POI) and who can be offered OTC safely.

Original language	English
Pages (from-to)	6-12
Number of pages	7
Journal	Fertility and Sterility
Volume	105
Issue number	1
Early online date	7 Dec 2015
DOIs	https://doi.org/10.1016/j.fertnstert.2015.11.041
Publication status	Published - Jan 2016

Keywords

Adolescent
Age Factors
Animals
Child
Child, Preschool
Cryopreservation
Female
Fertility
Fertility Preservation
Humans
Infant
Infant, Newborn
Infertility, Female
Neoplasms
Ovary
Patient Selection
Pregnancy
Primary Ovarian Insufficiency
Risk Factors
Survivors
Treatment Outcome
Journal Article
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.fertnstert.2015.11.041Licence: Unspecified

FandS21219_revision
© 2016, Publisher / the Author(s). This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://dx.doi.org/10.1016/j.fertnstert.2015.11.041
Accepted author manuscript, 621 KB

1 Abstract
1 Article

Effect of first line cancer treatment on the ovarian reserve and follicular density in girls under the age of 18 years
El Issaoui, M., Giorgine, V., Mamsen, L. S., Rechnitzer, C., Birkebæk, N., Clausen, N., Kelsey, T. W. & Andersen, C. Y., Dec 2016, In: Fertility and Sterility. 106, 7, p. 1757–1762.e1
Research output: Contribution to journal › Article › peer-review

Open Access
File
The effective sterilising dose of radiation for the human ovary
Kelsey, T. & Wallace, H., Nov 2015, In: Pediatric Blood & Cancer. 62, p. S308-S308 1 p.
Research output: Contribution to journal › Abstract › peer-review

Cite this

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title = "Fertility preservation in pre-pubertal girls with cancer: the role of ovarian tissue cryopreservation",

abstract = "With increasing numbers of survivors of cancer in young people future fertility and ovarian function are important considerations that should be discussed before treatment commences. Some young people, by nature of the treatment they will receive, are at high risk of premature ovarian insufficiency and infertility. For them, ovarian tissue cryopreservation (OTC) is one approach to fertility preservation that remains both invasive and for young patients experimental. There are important ethical and consent issues that need to be explored and accepted before OTC can be considered established in children with cancer. In this review we have discussed a framework for patient selection which has been shown to be effective in identifying those patients at high risk of premature ovarian insufficiency (POI) and who can be offered OTC safely.",

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author = "Wallace, {W Hamish B} and Kelsey, {Thomas W} and Anderson, {Richard A}",

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KW - Animals

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KW - Child, Preschool

KW - Cryopreservation

KW - Female

KW - Fertility

KW - Fertility Preservation

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Infertility, Female

KW - Neoplasms

KW - Ovary

KW - Patient Selection

KW - Pregnancy

KW - Primary Ovarian Insufficiency

KW - Risk Factors

KW - Survivors

KW - Treatment Outcome

KW - Journal Article

KW - Review

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Fertility preservation in pre-pubertal girls with cancer: the role of ovarian tissue cryopreservation

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Research output

Effect of first line cancer treatment on the ovarian reserve and follicular density in girls under the age of 18 years

The effective sterilising dose of radiation for the human ovary

Cite this