Fatty acid-depleted albumin induces the formation of echovirus A particles

T Ward, RM Powell, Y Chaudhry, J Meredith, JW Almond, W Kraus, B Nelsen-Salz, HJ Eggers, DJ Evans*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Picornavirus infection requires virus uncoating, associated with the production of 135S "A" particles and 80S empty particles from 160S mature virions, to release the RNA genome into the cell cytoplasm. Normal albumin inhibits this process. We now show that when depleted of fatty acids, albumin induces the formation of echovirus A particles.

Original languageEnglish
Pages (from-to)3410-3412
Number of pages3
JournalJournal of Virology
Volume74
Issue number7
Publication statusPublished - Apr 2000

Keywords

  • ACCELERATING FACTOR CD55
  • SOLUBLE CELL RECEPTORS
  • BOVINE ENTEROVIRUS
  • INHIBITION
  • RHODANINE

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