Factors influencing the response of MCF-7 cells to an agonist of luteinising hormone-releasing hormone

W N Scott; P Mullen; W R Miller

doi:10.1016/0277-5379(91)90031-8

Factors influencing the response of MCF-7 cells to an agonist of luteinising hormone-releasing hormone

W N Scott, P Mullen, W R Miller

Research output: Contribution to journal › Article › peer-review

Abstract

To clarify the mechanism by which the luteinising hormone-releasing hormone agonist, buserelin, may have direct effects on breast cancer cells, factors potentially influencing its action have been studied in the MCF-7 breast cancer cell line. Oestradiol and epidermal growth factor (EGF), which stimulate the growth of MCF-7 cells in culture, reversed, at least in part, the inhibitory effects of buserelin. Insulin also abolished growth inhibition. Quantitative effects of buserelin differed according to the batch of fetal calf serum used as media supplement. These data suggest that the direct inhibitory effects of buserelin on breast cancer cells are mediated at least in part by an antagonism of growth-promoting factors.

Original language	English
Pages (from-to)	1458-61
Number of pages	4
Journal	European Journal of Cancer
Volume	27
Issue number	11
DOIs	https://doi.org/10.1016/0277-5379(91)90031-8
Publication status	Published - 1991

Keywords

Breast Neoplasms/drug therapy
Buserelin/antagonists & inhibitors
Cell Line
Culture Media
Epidermal Growth Factor/pharmacology
Estradiol/pharmacology
Female
Gonadotropin-Releasing Hormone/physiology
Humans
Insulin/pharmacology
Tumor Cells, Cultured/drug effects

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0277-5379(91)90031-8

Cite this

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title = "Factors influencing the response of MCF-7 cells to an agonist of luteinising hormone-releasing hormone",

abstract = "To clarify the mechanism by which the luteinising hormone-releasing hormone agonist, buserelin, may have direct effects on breast cancer cells, factors potentially influencing its action have been studied in the MCF-7 breast cancer cell line. Oestradiol and epidermal growth factor (EGF), which stimulate the growth of MCF-7 cells in culture, reversed, at least in part, the inhibitory effects of buserelin. Insulin also abolished growth inhibition. Quantitative effects of buserelin differed according to the batch of fetal calf serum used as media supplement. These data suggest that the direct inhibitory effects of buserelin on breast cancer cells are mediated at least in part by an antagonism of growth-promoting factors.",

keywords = "Breast Neoplasms/drug therapy, Buserelin/antagonists & inhibitors, Cell Line, Culture Media, Epidermal Growth Factor/pharmacology, Estradiol/pharmacology, Female, Gonadotropin-Releasing Hormone/physiology, Humans, Insulin/pharmacology, Tumor Cells, Cultured/drug effects",

author = "Scott, {W N} and P Mullen and Miller, {W R}",

year = "1991",

doi = "10.1016/0277-5379(91)90031-8",

language = "English",

volume = "27",

pages = "1458--61",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Elsevier Inc.",

number = "11",

}

TY - JOUR

T1 - Factors influencing the response of MCF-7 cells to an agonist of luteinising hormone-releasing hormone

AU - Scott, W N

AU - Mullen, P

AU - Miller, W R

PY - 1991

Y1 - 1991

N2 - To clarify the mechanism by which the luteinising hormone-releasing hormone agonist, buserelin, may have direct effects on breast cancer cells, factors potentially influencing its action have been studied in the MCF-7 breast cancer cell line. Oestradiol and epidermal growth factor (EGF), which stimulate the growth of MCF-7 cells in culture, reversed, at least in part, the inhibitory effects of buserelin. Insulin also abolished growth inhibition. Quantitative effects of buserelin differed according to the batch of fetal calf serum used as media supplement. These data suggest that the direct inhibitory effects of buserelin on breast cancer cells are mediated at least in part by an antagonism of growth-promoting factors.

AB - To clarify the mechanism by which the luteinising hormone-releasing hormone agonist, buserelin, may have direct effects on breast cancer cells, factors potentially influencing its action have been studied in the MCF-7 breast cancer cell line. Oestradiol and epidermal growth factor (EGF), which stimulate the growth of MCF-7 cells in culture, reversed, at least in part, the inhibitory effects of buserelin. Insulin also abolished growth inhibition. Quantitative effects of buserelin differed according to the batch of fetal calf serum used as media supplement. These data suggest that the direct inhibitory effects of buserelin on breast cancer cells are mediated at least in part by an antagonism of growth-promoting factors.

KW - Breast Neoplasms/drug therapy

KW - Buserelin/antagonists & inhibitors

KW - Cell Line

KW - Culture Media

KW - Epidermal Growth Factor/pharmacology

KW - Estradiol/pharmacology

KW - Female

KW - Gonadotropin-Releasing Hormone/physiology

KW - Humans

KW - Insulin/pharmacology

KW - Tumor Cells, Cultured/drug effects

U2 - 10.1016/0277-5379(91)90031-8

DO - 10.1016/0277-5379(91)90031-8

M3 - Article

C2 - 1835862

SN - 0959-8049

VL - 27

SP - 1458

EP - 1461

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 11

ER -

Factors influencing the response of MCF-7 cells to an agonist of luteinising hormone-releasing hormone

Abstract

Keywords

UN SDGs

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