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Extending the utility of [Pd(NHC)(cinnamyl)Cl] precatalysts: Direct arylation of heterocycles

Anthony Martin, Anthony Raymond Georges Chartoire, Alexandra Martha Zoya Slawin, Steven Patrick Nolan

Research output: Contribution to journal › Article › peer-review

Abstract

The use of [Pd(NHC)(cinnamyl)Cl] precatalysts in the direct arylation of heterocycles has been investigated. Among four different precatalysts, [Pd(SIPr)(cinnamyl)Cl] proved to be the most efficient promoter of the reaction. The C–H functionalization of sulfuror nitrogen-containing heterocycles has been achieved at low catalyst loadings. These catalyst charges range from 0.1 to 0.01 mol % palladium.
Original languageEnglish
Pages (from-to)1637-1643
Number of pages7
JournalBeilstein Journal of Organic Chemistry
Volume8
DOIs
Publication statusPublished - 27 Sept 2012

Keywords

  • C-H functionalization
  • Direct arylation
  • Heterocycles
  • N-heterocyclic
  • Carbenes
  • Palladium

Access to Document

  • MartinetalBeilsteinJnlOrgChem2012 8Heterocycles

    © 2012 Martin et al; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)

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