Extending the utility of [Pd(NHC)(cinnamyl)Cl] precatalysts: Direct arylation of heterocycles

Anthony Martin, Anthony Raymond Georges Chartoire, Alexandra Martha Zoya Slawin, Steven Patrick Nolan

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)

Abstract

The use of [Pd(NHC)(cinnamyl)Cl] precatalysts in the direct arylation of heterocycles has been investigated. Among four different precatalysts, [Pd(SIPr)(cinnamyl)Cl] proved to be the most efficient promoter of the reaction. The C–H functionalization of sulfuror nitrogen-containing heterocycles has been achieved at low catalyst loadings. These catalyst charges range from 0.1 to 0.01 mol % palladium.
Original languageEnglish
Pages (from-to)1637-1643
Number of pages7
JournalBeilstein Journal of Organic Chemistry
Volume8
DOIs
Publication statusPublished - 27 Sept 2012

Keywords

  • C-H functionalization
  • Direct arylation
  • Heterocycles
  • N-heterocyclic
  • Carbenes
  • Palladium

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