TY - CHAP
T1 - Exploring ICP-MS as a versatile technique
T2 - from imaging to chemical speciation analysis
AU - Amais, Renata Stábile
AU - de Andrade, Aline Martins
AU - Santos da Silva, Ana Beatriz
AU - Freitas, Daniel Carneiro
AU - Francischini, Danielle da Silva
AU - Stewart, Alan J.
AU - Arruda, Marco Aurelio Zezzi
N1 - Funding: The authors thank the Sao Paulo Research Foundation (FAPESP, Sao Paulo, Brazil, 2017/50085-3, 2018/23478-7, 2018/25207-0, 2019/24445-8, 2020/02020-2, 2020/06934-9), the Brazilian National Council of Scientific and Technological Development (CNPq, Brasilia, Brazil, 401170/2016-0), INCTBio (FAPESP, Sao Paulo, Brazil, 2014/50867-3), and the Biotechnology and Biological Sciences Research Council (BBSRC, United Kingdom, BB/V014684/1), for the financial support and fellowships.
PY - 2022/5/24
Y1 - 2022/5/24
N2 - Elements plays important role in healthy, became key pieces of information in medicine and life science. In this sense, this chapter reviews the most recent advances in inductively coupled plasma mass spectrometry and its hyphenation with some techniques focusing on a diversity of applications. Here, we are exploring the state-of-the-art regarding ICP-MS platforms from elemental imaging to chemical speciation analysis, putting in evidence some applications as laser ablation in the imaging mode, single particle, and chemical speciation in studies involving cancer and neurodegenerative diseases, biomarkers, among others. We also examine current trends in this field, focusing on the further development of ICP-MS-based approaches as well as analytical, biochemical, and medical aspects associated with the use of trace element analysis.
AB - Elements plays important role in healthy, became key pieces of information in medicine and life science. In this sense, this chapter reviews the most recent advances in inductively coupled plasma mass spectrometry and its hyphenation with some techniques focusing on a diversity of applications. Here, we are exploring the state-of-the-art regarding ICP-MS platforms from elemental imaging to chemical speciation analysis, putting in evidence some applications as laser ablation in the imaging mode, single particle, and chemical speciation in studies involving cancer and neurodegenerative diseases, biomarkers, among others. We also examine current trends in this field, focusing on the further development of ICP-MS-based approaches as well as analytical, biochemical, and medical aspects associated with the use of trace element analysis.
KW - Trace elements
KW - Medical conditions
KW - Healthy
KW - Diseases
KW - Biomarkers
KW - Biological samples
KW - Sample preparation
KW - Nanoparticles
KW - Elemental imaging
KW - Hyphenated techniques
UR - https://doi.org/10.1016/s0166-526x(22)x0003-2
UR - https://discover.libraryhub.jisc.ac.uk/search?isn=9780444643476&rn=1
U2 - 10.1016/bs.coac.2022.02.004
DO - 10.1016/bs.coac.2022.02.004
M3 - Chapter
T3 - Comprehensive analytical chemistry
SP - 141
EP - 177
BT - ICP-MS and trace element analysis as tools for better understanding medical conditions
A2 - Arruda, Marco Aurélio Zezzi
A2 - de Jesus, Jemmyson Romário
PB - Elsevier
CY - Amsterdam
ER -
