Exploring helical peptides and foldamers for the design of metal helix frameworks: current trends and future perspectives

Nikhil Bajpayee; Thangavel Vijayakanth; Sigal Rencus-Lazar; Sneha Dasgupta; Aamod V. Desai; Rahul Jain; Ehud Gazit; Rajkumar Misra

doi:10.1002/anie.202214583

Exploring helical peptides and foldamers for the design of metal helix frameworks: current trends and future perspectives

Nikhil Bajpayee, Thangavel Vijayakanth, Sigal Rencus-Lazar, Sneha Dasgupta, Aamod V. Desai, Rahul Jain, Ehud Gazit^*, Rajkumar Misra^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Review article › peer-review

Abstract

Flexible and biocompatible metal peptide frameworks (MPFs) derived from short and ultra-short peptides have been explored for the storage of greenhouse gases, molecular recognition, and chiral transformations. In addition to short flexible peptides, peptides with specifically folded conformations have recently been utilized to fabricate a variety of metal helix frameworks (MHFs). The secondary structures of the peptides govern the structure-assembly relationship and thereby control the formation of three-dimensional (3D)-MHFs. Particularly, the hierarchical structural organization of peptide-based MHFs has not yet been discussed in detail. Here, we describe the recent progress of metal-driven folded peptide assembly to construct 3D porous structures for use in future energy storage, chiral recognition, and biomedical applications, which could be envisioned as an alternative to the conventional metal-organic frameworks (MOFs).

Original language	English
Article number	e202214583
Number of pages	12
Journal	Angewandte Chemie International Edition
Volume	62
Issue number	6
Early online date	15 Dec 2022
DOIs	https://doi.org/10.1002/anie.202214583
Publication status	Published - 1 Feb 2023

Keywords

Helical peptides
Foldamers
Metal-helix frameworks
Porous structures
Bio-compatibility

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Bajpayee_2022_ACIE_Exploring-Helical-Peptides_AAM
Copyright © 2022 Wiley-VCH GmbH. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1002/anie.202214583.
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title = "Exploring helical peptides and foldamers for the design of metal helix frameworks: current trends and future perspectives",

abstract = "Flexible and biocompatible metal peptide frameworks (MPFs) derived from short and ultra-short peptides have been explored for the storage of greenhouse gases, molecular recognition, and chiral transformations. In addition to short flexible peptides, peptides with specifically folded conformations have recently been utilized to fabricate a variety of metal helix frameworks (MHFs). The secondary structures of the peptides govern the structure-assembly relationship and thereby control the formation of three-dimensional (3D)-MHFs. Particularly, the hierarchical structural organization of peptide-based MHFs has not yet been discussed in detail. Here, we describe the recent progress of metal-driven folded peptide assembly to construct 3D porous structures for use in future energy storage, chiral recognition, and biomedical applications, which could be envisioned as an alternative to the conventional metal-organic frameworks (MOFs).",

keywords = "Helical peptides, Foldamers, Metal-helix frameworks, Porous structures, Bio-compatibility",

author = "Nikhil Bajpayee and Thangavel Vijayakanth and Sigal Rencus-Lazar and Sneha Dasgupta and \{V. Desai\}, Aamod and Rahul Jain and Ehud Gazit and Rajkumar Misra",

note = "Funding: T.V. thanks Tel Aviv University for the postdoctoral fellowship. E.G. thanks European Research Council PoC project Piezogel (966813) and Ministry of Science and Technology (MOST) Israel-China Program (3-19130). This research was supported by the DST Inspire Faculty Fellowship (No. DST/INSPIRE/04/2020/002499) from the Department of Science and Technology, New Delhi. R. M is also thankful to the National Institute of Pharmaceutical Education and Research, S. A. S. Nagar for providing the research facilities.",

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T1 - Exploring helical peptides and foldamers for the design of metal helix frameworks

T2 - current trends and future perspectives

AU - Bajpayee, Nikhil

AU - Vijayakanth, Thangavel

AU - Rencus-Lazar, Sigal

AU - Dasgupta, Sneha

AU - V. Desai, Aamod

AU - Jain, Rahul

AU - Gazit, Ehud

AU - Misra, Rajkumar

N1 - Funding: T.V. thanks Tel Aviv University for the postdoctoral fellowship. E.G. thanks European Research Council PoC project Piezogel (966813) and Ministry of Science and Technology (MOST) Israel-China Program (3-19130). This research was supported by the DST Inspire Faculty Fellowship (No. DST/INSPIRE/04/2020/002499) from the Department of Science and Technology, New Delhi. R. M is also thankful to the National Institute of Pharmaceutical Education and Research, S. A. S. Nagar for providing the research facilities.

PY - 2023/2/1

Y1 - 2023/2/1

N2 - Flexible and biocompatible metal peptide frameworks (MPFs) derived from short and ultra-short peptides have been explored for the storage of greenhouse gases, molecular recognition, and chiral transformations. In addition to short flexible peptides, peptides with specifically folded conformations have recently been utilized to fabricate a variety of metal helix frameworks (MHFs). The secondary structures of the peptides govern the structure-assembly relationship and thereby control the formation of three-dimensional (3D)-MHFs. Particularly, the hierarchical structural organization of peptide-based MHFs has not yet been discussed in detail. Here, we describe the recent progress of metal-driven folded peptide assembly to construct 3D porous structures for use in future energy storage, chiral recognition, and biomedical applications, which could be envisioned as an alternative to the conventional metal-organic frameworks (MOFs).

AB - Flexible and biocompatible metal peptide frameworks (MPFs) derived from short and ultra-short peptides have been explored for the storage of greenhouse gases, molecular recognition, and chiral transformations. In addition to short flexible peptides, peptides with specifically folded conformations have recently been utilized to fabricate a variety of metal helix frameworks (MHFs). The secondary structures of the peptides govern the structure-assembly relationship and thereby control the formation of three-dimensional (3D)-MHFs. Particularly, the hierarchical structural organization of peptide-based MHFs has not yet been discussed in detail. Here, we describe the recent progress of metal-driven folded peptide assembly to construct 3D porous structures for use in future energy storage, chiral recognition, and biomedical applications, which could be envisioned as an alternative to the conventional metal-organic frameworks (MOFs).

KW - Helical peptides

KW - Foldamers

KW - Metal-helix frameworks

KW - Porous structures

KW - Bio-compatibility

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U2 - 10.1002/anie.202214583

DO - 10.1002/anie.202214583

M3 - Review article

SN - 1433-7851

VL - 62

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

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M1 - e202214583

ER -

Exploring helical peptides and foldamers for the design of metal helix frameworks: current trends and future perspectives

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Keywords

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