Exploring helical peptides and foldamers for the design of metal helix frameworks: current trends and future perspectives

Nikhil Bajpayee, Thangavel Vijayakanth, Sigal Rencus-Lazar, Sneha Dasgupta, Aamod V. Desai, Rahul Jain, Ehud Gazit*, Rajkumar Misra*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)
9 Downloads (Pure)

Abstract

Flexible and biocompatible metal peptide frameworks (MPFs) derived from short and ultra-short peptides have been explored for the storage of greenhouse gases, molecular recognition, and chiral transformations. In addition to short flexible peptides, peptides with specifically folded conformations have recently been utilized to fabricate a variety of metal helix frameworks (MHFs). The secondary structures of the peptides govern the structure-assembly relationship and thereby control the formation of three-dimensional (3D)-MHFs. Particularly, the hierarchical structural organization of peptide-based MHFs has not yet been discussed in detail. Here, we describe the recent progress of metal-driven folded peptide assembly to construct 3D porous structures for use in future energy storage, chiral recognition, and biomedical applications, which could be envisioned as an alternative to the conventional metal-organic frameworks (MOFs).
Original languageEnglish
Article numbere202214583
Number of pages12
JournalAngewandte Chemie International Edition
Volume62
Issue number6
Early online date15 Dec 2022
DOIs
Publication statusPublished - 1 Feb 2023

Keywords

  • Helical peptides
  • Foldamers
  • Metal-helix frameworks
  • Porous structures
  • Bio-compatibility

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