Exploiting the Curtin-Hammett principle-recognition-mediated acceleration of an aldol reaction

S J Howell, P R Ashton, N Spencer, D Philp

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

[GRAPHICS]

Curtin-Hammett-Winstein-Holness kinetics are exploited in the acceleration of the aldol reaction between formylbenzo-15-crown-5 and acetylbenzo-15-crown-5. Potassium cations facilitate this acceleration through the fast, reversible formation of a 1:1:1 sandwich complex between the crown ethers and the metal cation.

Original languageEnglish
Pages (from-to)353-356
Number of pages4
JournalOrganic Letters
Volume3
Issue number3
Early online date12 Jan 2001
DOIs
Publication statusPublished - 8 Feb 2001

Keywords

  • INTRAMOLECULAR REACTIONS
  • CYCLOADDITION
  • COMPLEXES

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