Expeditious Synthesis of [Au(NHC)(L)](+) (NHC = N-Heterocyclic Carbene; L = Phosphine or NHC) Complexes

Sylvain Gaillard; Pierrick Nun; Alexandra M. Z. Slawin; Steven P. Nolan

doi:10.1021/om100456b

Expeditious Synthesis of [Au(NHC)(L)](+) (NHC = N-Heterocyclic Carbene; L = Phosphine or NHC) Complexes

Sylvain Gaillard, Pierrick Nun, Alexandra M. Z. Slawin, Steven P. Nolan

Research output: Contribution to journal › Article › peer-review

Abstract

The use of the versatile N-heterocyclic carbene (NHC) gold(I) hydroxide [Au(OH)(IPr)] (IPr = N,N '-bis(2,6-diisopropylpheny)imidazol-2-ylidene) as precursor permits the expedient synthesis of a series of cationic heteroleptic [Au(NHC)(NHC')](+) and [Au(NHC)(PR3)](+) complexes by proton. lysis with the appropriate acid salts. Complete characterization by H-1 and C-13 NMR spectroscopy and by single-crystal X-ray diffraction was performed in order to discern electronic and structural differences between cationic heteroleptic [Au(NHC)(NHC')](+) and [Au(NHC)(PR3)](+) congeners.

Original language	English
Pages (from-to)	5402-5408
Number of pages	7
Journal	Organometallics
Volume	29
Issue number	21
DOIs	https://doi.org/10.1021/om100456b
Publication status	Published - 8 Nov 2010

Keywords

GOLD(I) COMPLEXES
ANTICANCER AGENT
METAL-COMPLEXES
PHASE-I
CYTOTOXICITY
DERIVATIVES
LIGANDS
BEARING

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title = "Expeditious Synthesis of [Au(NHC)(L)](+) (NHC = N-Heterocyclic Carbene; L = Phosphine or NHC) Complexes",

abstract = "The use of the versatile N-heterocyclic carbene (NHC) gold(I) hydroxide [Au(OH)(IPr)] (IPr = N,N '-bis(2,6-diisopropylpheny)imidazol-2-ylidene) as precursor permits the expedient synthesis of a series of cationic heteroleptic [Au(NHC)(NHC')](+) and [Au(NHC)(PR3)](+) complexes by proton. lysis with the appropriate acid salts. Complete characterization by H-1 and C-13 NMR spectroscopy and by single-crystal X-ray diffraction was performed in order to discern electronic and structural differences between cationic heteroleptic [Au(NHC)(NHC')](+) and [Au(NHC)(PR3)](+) congeners.",

keywords = "GOLD(I) COMPLEXES, ANTICANCER AGENT, METAL-COMPLEXES, PHASE-I, CYTOTOXICITY, DERIVATIVES, LIGANDS, BEARING",

author = "Sylvain Gaillard and Pierrick Nun and Slawin, {Alexandra M. Z.} and Nolan, {Steven P.}",

year = "2010",

month = nov,

day = "8",

doi = "10.1021/om100456b",

language = "English",

volume = "29",

pages = "5402--5408",

journal = "Organometallics",

issn = "0276-7333",

publisher = "American Chemical Society (ACS)",

number = "21",

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TY - JOUR

T1 - Expeditious Synthesis of [Au(NHC)(L)](+) (NHC = N-Heterocyclic Carbene; L = Phosphine or NHC) Complexes

AU - Gaillard, Sylvain

AU - Nun, Pierrick

AU - Slawin, Alexandra M. Z.

AU - Nolan, Steven P.

PY - 2010/11/8

Y1 - 2010/11/8

N2 - The use of the versatile N-heterocyclic carbene (NHC) gold(I) hydroxide [Au(OH)(IPr)] (IPr = N,N '-bis(2,6-diisopropylpheny)imidazol-2-ylidene) as precursor permits the expedient synthesis of a series of cationic heteroleptic [Au(NHC)(NHC')](+) and [Au(NHC)(PR3)](+) complexes by proton. lysis with the appropriate acid salts. Complete characterization by H-1 and C-13 NMR spectroscopy and by single-crystal X-ray diffraction was performed in order to discern electronic and structural differences between cationic heteroleptic [Au(NHC)(NHC')](+) and [Au(NHC)(PR3)](+) congeners.

AB - The use of the versatile N-heterocyclic carbene (NHC) gold(I) hydroxide [Au(OH)(IPr)] (IPr = N,N '-bis(2,6-diisopropylpheny)imidazol-2-ylidene) as precursor permits the expedient synthesis of a series of cationic heteroleptic [Au(NHC)(NHC')](+) and [Au(NHC)(PR3)](+) complexes by proton. lysis with the appropriate acid salts. Complete characterization by H-1 and C-13 NMR spectroscopy and by single-crystal X-ray diffraction was performed in order to discern electronic and structural differences between cationic heteroleptic [Au(NHC)(NHC')](+) and [Au(NHC)(PR3)](+) congeners.

KW - GOLD(I) COMPLEXES

KW - ANTICANCER AGENT

KW - METAL-COMPLEXES

KW - PHASE-I

KW - CYTOTOXICITY

KW - DERIVATIVES

KW - LIGANDS

KW - BEARING

U2 - 10.1021/om100456b

DO - 10.1021/om100456b

M3 - Article

SN - 0276-7333

VL - 29

SP - 5402

EP - 5408

JO - Organometallics

JF - Organometallics

IS - 21

ER -

Expeditious Synthesis of [Au(NHC)(L)](+) (NHC = N-Heterocyclic Carbene; L = Phosphine or NHC) Complexes

Abstract

Keywords

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