Expeditious Synthesis of [Au(NHC)(L)](+) (NHC = N-Heterocyclic Carbene; L = Phosphine or NHC) Complexes

Sylvain Gaillard, Pierrick Nun, Alexandra M. Z. Slawin, Steven P. Nolan

Research output: Contribution to journalArticlepeer-review

81 Citations (Scopus)

Abstract

The use of the versatile N-heterocyclic carbene (NHC) gold(I) hydroxide [Au(OH)(IPr)] (IPr = N,N '-bis(2,6-diisopropylpheny)imidazol-2-ylidene) as precursor permits the expedient synthesis of a series of cationic heteroleptic [Au(NHC)(NHC')](+) and [Au(NHC)(PR3)](+) complexes by proton. lysis with the appropriate acid salts. Complete characterization by H-1 and C-13 NMR spectroscopy and by single-crystal X-ray diffraction was performed in order to discern electronic and structural differences between cationic heteroleptic [Au(NHC)(NHC')](+) and [Au(NHC)(PR3)](+) congeners.

Original languageEnglish
Pages (from-to)5402-5408
Number of pages7
JournalOrganometallics
Volume29
Issue number21
DOIs
Publication statusPublished - 8 Nov 2010

Keywords

  • GOLD(I) COMPLEXES
  • ANTICANCER AGENT
  • METAL-COMPLEXES
  • PHASE-I
  • CYTOTOXICITY
  • DERIVATIVES
  • LIGANDS
  • BEARING

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