Expedient syntheses of neutral and cationic Au(I)–NHC complexes

Richard M. P. Veenboer; Danila Gasperini; Fady Nahra; David B. Cordes; Alexandra M. Z. Slawin; Catherine S. J. Cazin; Steven P. Nolan

doi:10.1021/acs.organomet.7b00622

Expedient syntheses of neutral and cationic Au(I)–NHC complexes

Richard M. P. Veenboer, Danila Gasperini, Fady Nahra, David B. Cordes, Alexandra M. Z. Slawin, Catherine S. J. Cazin, Steven P. Nolan

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis and isolation of gold(I) precatalysts often requires the generation of several isolable intermediates as well as numerous purification steps. New protocols for the expedient synthesis of neutral [Au(OH)(NHC)] and [Au(CH₂COCH₃)(NHC)] species from [AuCl(NHC)] or [AuCl(DMS)] precursors bearing a variety of N-heterocyclic carbene (NHC) ligands are presented. These methods can be employed in a telescoping manner for the synthesis of catalytically relevant [Au(NTf₂)(NHC)] and [Au(NHC)(NCCH₃)][BF₄] complexes. These attractive methods are straightforward and practical leading to various complexes in high isolated yields and purity.

Original language	English
Pages (from-to)	3645–3653
Journal	Organometallics
Volume	36
Issue number	18
Early online date	8 Sept 2017
DOIs	https://doi.org/10.1021/acs.organomet.7b00622
Publication status	Published - 25 Sept 2017

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10.1021/acs.organomet.7b00622

Cordes_2017_Organometallics_NeutralandCationic_AAM
Copyright © 2017 American Chemical Society. This work has been made available online in accordance with the publisher’s policies. This is the author created accepted version manuscript following peer review and as such may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1021/acs.organomet.7b00622
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Cite this

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title = "Expedient syntheses of neutral and cationic Au(I)–NHC complexes",

abstract = "The synthesis and isolation of gold(I) precatalysts often requires the generation of several isolable intermediates as well as numerous purification steps. New protocols for the expedient synthesis of neutral [Au(OH)(NHC)] and [Au(CH2COCH3)(NHC)] species from [AuCl(NHC)] or [AuCl(DMS)] precursors bearing a variety of N-heterocyclic carbene (NHC) ligands are presented. These methods can be employed in a telescoping manner for the synthesis of catalytically relevant [Au(NTf2)(NHC)] and [Au(NHC)(NCCH3)][BF4] complexes. These attractive methods are straightforward and practical leading to various complexes in high isolated yields and purity.",

author = "Veenboer, {Richard M. P.} and Danila Gasperini and Fady Nahra and Cordes, {David B.} and Slawin, {Alexandra M. Z.} and Cazin, {Catherine S. J.} and Nolan, {Steven P.}",

note = "The European Research Council (ERC) and the Engineering and Physical Sciences Research Council (EPSRC), UK are gratefully acknowledged for their support. Umicore AG is thanked for generous donations of auric acid. S.P.N. thanks the King Abdullah University of Science and Technology (KAUST) for support. ",

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doi = "10.1021/acs.organomet.7b00622",

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T1 - Expedient syntheses of neutral and cationic Au(I)–NHC complexes

AU - Veenboer, Richard M. P.

AU - Gasperini, Danila

AU - Nahra, Fady

AU - Cordes, David B.

AU - Slawin, Alexandra M. Z.

AU - Cazin, Catherine S. J.

AU - Nolan, Steven P.

N1 - The European Research Council (ERC) and the Engineering and Physical Sciences Research Council (EPSRC), UK are gratefully acknowledged for their support. Umicore AG is thanked for generous donations of auric acid. S.P.N. thanks the King Abdullah University of Science and Technology (KAUST) for support.

PY - 2017/9/25

Y1 - 2017/9/25

N2 - The synthesis and isolation of gold(I) precatalysts often requires the generation of several isolable intermediates as well as numerous purification steps. New protocols for the expedient synthesis of neutral [Au(OH)(NHC)] and [Au(CH2COCH3)(NHC)] species from [AuCl(NHC)] or [AuCl(DMS)] precursors bearing a variety of N-heterocyclic carbene (NHC) ligands are presented. These methods can be employed in a telescoping manner for the synthesis of catalytically relevant [Au(NTf2)(NHC)] and [Au(NHC)(NCCH3)][BF4] complexes. These attractive methods are straightforward and practical leading to various complexes in high isolated yields and purity.

AB - The synthesis and isolation of gold(I) precatalysts often requires the generation of several isolable intermediates as well as numerous purification steps. New protocols for the expedient synthesis of neutral [Au(OH)(NHC)] and [Au(CH2COCH3)(NHC)] species from [AuCl(NHC)] or [AuCl(DMS)] precursors bearing a variety of N-heterocyclic carbene (NHC) ligands are presented. These methods can be employed in a telescoping manner for the synthesis of catalytically relevant [Au(NTf2)(NHC)] and [Au(NHC)(NCCH3)][BF4] complexes. These attractive methods are straightforward and practical leading to various complexes in high isolated yields and purity.

UR - http://pubs.acs.org/doi/suppl/10.1021/acs.organomet.7b00622

U2 - 10.1021/acs.organomet.7b00622

DO - 10.1021/acs.organomet.7b00622

M3 - Article

SN - 0276-7333

VL - 36

SP - 3645

EP - 3653

JO - Organometallics

JF - Organometallics

IS - 18

ER -

Expedient syntheses of neutral and cationic Au(I)–NHC complexes

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