Excitotoxic lesions of the subthalamic nucleus ameliorate asymmetry induced by striatal dopamine depletion in the rat

Janice M. Phillips; Mary P. Latimer; Sonali Gupta; Philip Winn; Verity J. Brown

doi:10.1016/S0166-4328(97)00080-6

Excitotoxic lesions of the subthalamic nucleus ameliorate asymmetry induced by striatal dopamine depletion in the rat

Janice M. Phillips^*, Mary P. Latimer, Sonali Gupta, Philip Winn, Verity J. Brown

^*Corresponding author for this work

School of Psychology and Neuroscience

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the effect of unilateral dorsal striatal dopamine depletion (by intrastriatal infusion of 6-OHDA), ibotenic acid lesions of the subthalamic nucleus (STN) and combined dopamine depletion and STN lesions on sensorimotor asymmetry using a test of somatosensory asymmetry [T. Schallert et al., Pharmacol. Biochem. Behav. 16 (1982) 455-462]. The unilateral striatal dopamine depletion resulted in a somatosensory asymmetry. This asymmetry was ameliorated in the rats with combined dopamine depletion and STN lesion, indicating the potential beneficial nature of STN inactivation in rats with striatal dopamine depletion.

Original language	English
Pages (from-to)	73-77
Number of pages	5
Journal	Behavioural Brain Research
Volume	90
Issue number	1
DOIs	https://doi.org/10.1016/S0166-4328(97)00080-6
Publication status	Published - 1 Jan 1998

Keywords

Basal ganglia
Parkinson's disease
Rat
Sensorimotor asymmetry
Subthalamic nucleus

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title = "Excitotoxic lesions of the subthalamic nucleus ameliorate asymmetry induced by striatal dopamine depletion in the rat",

abstract = "We investigated the effect of unilateral dorsal striatal dopamine depletion (by intrastriatal infusion of 6-OHDA), ibotenic acid lesions of the subthalamic nucleus (STN) and combined dopamine depletion and STN lesions on sensorimotor asymmetry using a test of somatosensory asymmetry [T. Schallert et al., Pharmacol. Biochem. Behav. 16 (1982) 455-462]. The unilateral striatal dopamine depletion resulted in a somatosensory asymmetry. This asymmetry was ameliorated in the rats with combined dopamine depletion and STN lesion, indicating the potential beneficial nature of STN inactivation in rats with striatal dopamine depletion.",

keywords = "Basal ganglia, Parkinson's disease, Rat, Sensorimotor asymmetry, Subthalamic nucleus",

author = "Phillips, \{Janice M.\} and Latimer, \{Mary P.\} and Sonali Gupta and Philip Winn and Brown, \{Verity J.\}",

year = "1998",

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doi = "10.1016/S0166-4328(97)00080-6",

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T1 - Excitotoxic lesions of the subthalamic nucleus ameliorate asymmetry induced by striatal dopamine depletion in the rat

AU - Phillips, Janice M.

AU - Latimer, Mary P.

AU - Gupta, Sonali

AU - Winn, Philip

AU - Brown, Verity J.

PY - 1998/1/1

Y1 - 1998/1/1

N2 - We investigated the effect of unilateral dorsal striatal dopamine depletion (by intrastriatal infusion of 6-OHDA), ibotenic acid lesions of the subthalamic nucleus (STN) and combined dopamine depletion and STN lesions on sensorimotor asymmetry using a test of somatosensory asymmetry [T. Schallert et al., Pharmacol. Biochem. Behav. 16 (1982) 455-462]. The unilateral striatal dopamine depletion resulted in a somatosensory asymmetry. This asymmetry was ameliorated in the rats with combined dopamine depletion and STN lesion, indicating the potential beneficial nature of STN inactivation in rats with striatal dopamine depletion.

AB - We investigated the effect of unilateral dorsal striatal dopamine depletion (by intrastriatal infusion of 6-OHDA), ibotenic acid lesions of the subthalamic nucleus (STN) and combined dopamine depletion and STN lesions on sensorimotor asymmetry using a test of somatosensory asymmetry [T. Schallert et al., Pharmacol. Biochem. Behav. 16 (1982) 455-462]. The unilateral striatal dopamine depletion resulted in a somatosensory asymmetry. This asymmetry was ameliorated in the rats with combined dopamine depletion and STN lesion, indicating the potential beneficial nature of STN inactivation in rats with striatal dopamine depletion.

KW - Basal ganglia

KW - Parkinson's disease

KW - Rat

KW - Sensorimotor asymmetry

KW - Subthalamic nucleus

UR - https://www.scopus.com/pages/publications/0031887457

U2 - 10.1016/S0166-4328(97)00080-6

DO - 10.1016/S0166-4328(97)00080-6

M3 - Article

C2 - 9520214

AN - SCOPUS:0031887457

SN - 0166-4328

VL - 90

SP - 73

EP - 77

JO - Behavioural Brain Research

JF - Behavioural Brain Research

IS - 1

ER -

Excitotoxic lesions of the subthalamic nucleus ameliorate asymmetry induced by striatal dopamine depletion in the rat

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