Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness

Katarzyna Bozek; Yuning Wei; Zheng Yan; Xiling Liu; Jieyi Xiong; Masahiro Sugimoto; Masaru Tomita; Svante Paeaebo; Raik Pieszek; Chet C. Sherwood; Patrick R. Hof; John J. Ely; Dirk Steinhauser; Lothar Willmitzer; Jens Bangsbo; Ola Hansson; Josep Call; Patrick Giavalisco; Philipp Khaitovich

doi:10.1371/journal.pbio.1001871

Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness

Katarzyna Bozek^*, Yuning Wei, Zheng Yan, Xiling Liu, Jieyi Xiong, Masahiro Sugimoto, Masaru Tomita, Svante Paeaebo, Raik Pieszek, Chet C. Sherwood, Patrick R. Hof, John J. Ely, Dirk Steinhauser, Lothar Willmitzer, Jens Bangsbo, Ola Hansson, Josep Call, Patrick Giavalisco, Philipp Khaitovich

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Metabolite concentrations reflect the physiological states of tissues and cells. However, the role of metabolic changes in species evolution is currently unknown. Here, we present a study of metabolome evolution conducted in three brain regions and two non-neural tissues from humans, chimpanzees, macaque monkeys, and mice based on over 10,000 hydrophilic compounds. While chimpanzee, macaque, and mouse metabolomes diverge following the genetic distances among species, we detect remarkable acceleration of metabolome evolution in human prefrontal cortex and skeletal muscle affecting neural and energy metabolism pathways. These metabolic changes could not be attributed to environmental conditions and were confirmed against the expression of their corresponding enzymes. We further conducted muscle strength tests in humans, chimpanzees, and macaques. The results suggest that, while humans are characterized by superior cognition, their muscular performance might be markedly inferior to that of chimpanzees and macaque monkeys.

Original language	English
Article number	e1001871
Number of pages	14
Journal	PLoS Biology
Volume	12
Issue number	5
DOIs	https://doi.org/10.1371/journal.pbio.1001871
Publication status	Published - 27 May 2014

Keywords

Mass-spectrometry
Pan-troglodytes
Chimpanzee
Metabolites
Strength
Homo

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Bozek, K., Wei, Y., Yan, Z., Liu, X., Xiong, J., Sugimoto, M., Tomita, M., Paeaebo, S., Pieszek, R., Sherwood, C. C., Hof, P. R., Ely, J. J., Steinhauser, D., Willmitzer, L., Bangsbo, J., Hansson, O., Call, J., Giavalisco, P., & Khaitovich, P. (2014). Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness. PLoS Biology, 12(5), Article e1001871. https://doi.org/10.1371/journal.pbio.1001871

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Bozek, K, Wei, Y, Yan, Z, Liu, X, Xiong, J, Sugimoto, M, Tomita, M, Paeaebo, S, Pieszek, R, Sherwood, CC, Hof, PR, Ely, JJ, Steinhauser, D, Willmitzer, L, Bangsbo, J, Hansson, O, Call, J, Giavalisco, P & Khaitovich, P 2014, 'Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness', PLoS Biology, vol. 12, no. 5, e1001871. https://doi.org/10.1371/journal.pbio.1001871

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AU - Bozek, Katarzyna

AU - Wei, Yuning

AU - Yan, Zheng

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AU - Sugimoto, Masahiro

AU - Tomita, Masaru

AU - Paeaebo, Svante

AU - Pieszek, Raik

AU - Sherwood, Chet C.

AU - Hof, Patrick R.

AU - Ely, John J.

AU - Steinhauser, Dirk

AU - Willmitzer, Lothar

AU - Bangsbo, Jens

AU - Hansson, Ola

AU - Call, Josep

AU - Giavalisco, Patrick

AU - Khaitovich, Philipp

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Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness

Abstract

Keywords

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