Evolution of MRSA During Hospital Transmission and Intercontinental Spread

Simon R. Harris; Edward J. Feil; Matthew Thomas Geoffrey Holden; Michael A. Quail; Emma K. Nickerson; Narisara Chantratita; Susana Gardete; Ana Tavares; Nick Day; Jodi A. Lindsay; Jonathan D. Edgeworth; Herminia de Lencastre; Julian Parkhill; Sharon J. Peacock; Stephen D. Bentley

doi:10.1126/science.1182395

Evolution of MRSA During Hospital Transmission and Intercontinental Spread

Simon R. Harris, Edward J. Feil, Matthew Thomas Geoffrey Holden, Michael A. Quail, Emma K. Nickerson, Narisara Chantratita, Susana Gardete, Ana Tavares, Nick Day, Jodi A. Lindsay, Jonathan D. Edgeworth, Herminia de Lencastre, Julian Parkhill, Sharon J. Peacock, Stephen D. Bentley^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a high-throughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global geographic structure within the lineage, its intercontinental transmission through four decades, and the potential to trace person-to-person transmission within a hospital environment. The ability to interrogate and resolve bacterial populations is applicable to a range of infectious diseases, as well as microbial ecology.

Original language	English
Pages (from-to)	469-474
Number of pages	6
Journal	Science
Volume	327
Issue number	5964
DOIs	https://doi.org/10.1126/science.1182395
Publication status	Published - 22 Jan 2010

Keywords

RESISTANT STAPHYLOCOCCUS-AUREUS
IDENTIFICATION
CLONES
TRIMETHOPRIM
MUTATION
STRAIN

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1126/science.1182395

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Harris, S. R., Feil, E. J., Holden, M. T. G., Quail, M. A., Nickerson, E. K., Chantratita, N., Gardete, S., Tavares, A., Day, N., Lindsay, J. A., Edgeworth, J. D., de Lencastre, H., Parkhill, J., Peacock, S. J., & Bentley, S. D. (2010). Evolution of MRSA During Hospital Transmission and Intercontinental Spread. Science, 327(5964), 469-474. https://doi.org/10.1126/science.1182395

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title = "Evolution of MRSA During Hospital Transmission and Intercontinental Spread",

abstract = "Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a high-throughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global geographic structure within the lineage, its intercontinental transmission through four decades, and the potential to trace person-to-person transmission within a hospital environment. The ability to interrogate and resolve bacterial populations is applicable to a range of infectious diseases, as well as microbial ecology.",

keywords = "RESISTANT STAPHYLOCOCCUS-AUREUS, IDENTIFICATION, CLONES, TRIMETHOPRIM, MUTATION, STRAIN",

author = "Harris, {Simon R.} and Feil, {Edward J.} and Holden, {Matthew Thomas Geoffrey} and Quail, {Michael A.} and Nickerson, {Emma K.} and Narisara Chantratita and Susana Gardete and Ana Tavares and Nick Day and Lindsay, {Jodi A.} and Edgeworth, {Jonathan D.} and {de Lencastre}, Herminia and Julian Parkhill and Peacock, {Sharon J.} and Bentley, {Stephen D.}",

year = "2010",

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doi = "10.1126/science.1182395",

language = "English",

volume = "327",

pages = "469--474",

journal = "Science",

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TY - JOUR

T1 - Evolution of MRSA During Hospital Transmission and Intercontinental Spread

AU - Harris, Simon R.

AU - Feil, Edward J.

AU - Holden, Matthew Thomas Geoffrey

AU - Quail, Michael A.

AU - Nickerson, Emma K.

AU - Chantratita, Narisara

AU - Gardete, Susana

AU - Tavares, Ana

AU - Day, Nick

AU - Lindsay, Jodi A.

AU - Edgeworth, Jonathan D.

AU - de Lencastre, Herminia

AU - Parkhill, Julian

AU - Peacock, Sharon J.

AU - Bentley, Stephen D.

PY - 2010/1/22

Y1 - 2010/1/22

N2 - Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a high-throughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global geographic structure within the lineage, its intercontinental transmission through four decades, and the potential to trace person-to-person transmission within a hospital environment. The ability to interrogate and resolve bacterial populations is applicable to a range of infectious diseases, as well as microbial ecology.

AB - Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a high-throughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global geographic structure within the lineage, its intercontinental transmission through four decades, and the potential to trace person-to-person transmission within a hospital environment. The ability to interrogate and resolve bacterial populations is applicable to a range of infectious diseases, as well as microbial ecology.

KW - RESISTANT STAPHYLOCOCCUS-AUREUS

KW - IDENTIFICATION

KW - CLONES

KW - TRIMETHOPRIM

KW - MUTATION

KW - STRAIN

U2 - 10.1126/science.1182395

DO - 10.1126/science.1182395

M3 - Article

SN - 0036-8075

VL - 327

SP - 469

EP - 474

JO - Science

JF - Science

IS - 5964

ER -

Evolution of MRSA During Hospital Transmission and Intercontinental Spread

Abstract

Keywords

UN SDGs

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