Evidence for the Reversible Acylation of Elastases by Monocyclic g-Lactams

Nicholas James Westwood; CJ Schofield; TWD Claridge; P Edwards

Evidence for the Reversible Acylation of Elastases by Monocyclic g-Lactams

Nicholas James Westwood, CJ Schofield, TWD Claridge, P Edwards

Research output: Other contribution

Abstract

The reaction of a monocyclic gamma-lactam with the serine protease elastase occurs via reversible formation of a hydrolytically labile acyl-enzyme complex; in contrast analogous beta-lactam inhibitors irreversibly react to form a relatively stable acyl-enzyme complex. (C) 1997 Elsevier Science Ltd.

Original language	English
Volume	7
Publication status	Published - 2 Dec 1997

Keywords

HUMAN-LEUKOCYTE ELASTASE
STEREOSPECIFIC SYNTHESIS
ACID
ANTIBIOTICS
BINDING

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title = "Evidence for the Reversible Acylation of Elastases by Monocyclic g-Lactams",

abstract = "The reaction of a monocyclic gamma-lactam with the serine protease elastase occurs via reversible formation of a hydrolytically labile acyl-enzyme complex; in contrast analogous beta-lactam inhibitors irreversibly react to form a relatively stable acyl-enzyme complex. (C) 1997 Elsevier Science Ltd.",

keywords = "HUMAN-LEUKOCYTE ELASTASE, STEREOSPECIFIC SYNTHESIS, ACID, ANTIBIOTICS, BINDING",

author = "Westwood, {Nicholas James} and CJ Schofield and TWD Claridge and P Edwards",

note = "Bioorg Med Chem Letts",

year = "1997",

month = dec,

day = "2",

language = "English",

volume = "7",

type = "Other",

}

TY - GEN

T1 - Evidence for the Reversible Acylation of Elastases by Monocyclic g-Lactams

AU - Westwood, Nicholas James

AU - Schofield, CJ

AU - Claridge, TWD

AU - Edwards, P

N1 - Bioorg Med Chem Letts

PY - 1997/12/2

Y1 - 1997/12/2

N2 - The reaction of a monocyclic gamma-lactam with the serine protease elastase occurs via reversible formation of a hydrolytically labile acyl-enzyme complex; in contrast analogous beta-lactam inhibitors irreversibly react to form a relatively stable acyl-enzyme complex. (C) 1997 Elsevier Science Ltd.

AB - The reaction of a monocyclic gamma-lactam with the serine protease elastase occurs via reversible formation of a hydrolytically labile acyl-enzyme complex; in contrast analogous beta-lactam inhibitors irreversibly react to form a relatively stable acyl-enzyme complex. (C) 1997 Elsevier Science Ltd.

KW - HUMAN-LEUKOCYTE ELASTASE

KW - STEREOSPECIFIC SYNTHESIS

KW - ACID

KW - ANTIBIOTICS

KW - BINDING

M3 - Other contribution

VL - 7

ER -

Evidence for the Reversible Acylation of Elastases by Monocyclic g-Lactams

Abstract

Keywords

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