Evidence for a genetic basis of urogenital carcinoma in the wild California sea lion

Helen M. Browning; Karina Acevedo-Whitehouse; Frances M. D. Gulland; Ailsa J. Hall; Jeanie Finlayson; Mark P. Dagleish; Karen J. Billington; Kathleen Colegrove; John A. Hammond

doi:10.1098/rspb.2014.0240

Evidence for a genetic basis of urogenital carcinoma in the wild California sea lion

Helen M. Browning, Karina Acevedo-Whitehouse, Frances M. D. Gulland, Ailsa J. Hall, Jeanie Finlayson, Mark P. Dagleish, Karen J. Billington, Kathleen Colegrove, John A. Hammond

Research output: Contribution to journal › Article › peer-review

Abstract

Although neoplasia is a major cause of mortality in humans and domestic animals, it has rarely been described in wildlife species. One of the fewexamples
is a highly prevalent urogenital carcinoma in California sea lions (CSLs).
Although the aetiology of this carcinoma is clearly multifactorial, inbreeding
depression, as estimated using levels of microsatellite multilocus heterozygosity,
is identified as predictive for this neoplasia. On further analysis, this
relationship appears to be largely driven by one marker, suggesting that a
single locus might be associated with the occurrence of this disease in CSLs.
In a case–control study, carcinoma was significantly associated with homozygosity at the Pv11 microsatellite locus. Pv11 was mapped to intron 9 of
the heparanase 2 gene (HPSE2) locus, a very large gene encoding heparanase
2, which in humans is associated with multiple carcinomas. Correspondingly,
immunohistochemical labelling in tissues was present in carcinoma cases
within a single homozygous Pv11 genotype. To our knowledge, this is the
first report of an individual locus being associated with cancer in any wildlife
species. This adds emphasis to the study of HPSE2 in other species, including
humans and will guide future studies on this sentinel species that shares much
of its diet and environment with humans

Original language	English
Article number	20140240
Number of pages	10
Journal	Proceedings of the Royal Society B: Biological Sciences
Volume	281
Issue number	1796
Early online date	22 Oct 2014
DOIs	https://doi.org/10.1098/rspb.2014.0240
Publication status	Published - Dec 2014

Keywords

Cancer
Heparanase 2 gene
Wildlife
Odds ratio

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1098/rspb.2014.0240

browning2014procroyalsocb20140240
© 2014. The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
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Cite this

Browning, H. M., Acevedo-Whitehouse, K., Gulland, F. M. D., Hall, A. J., Finlayson, J., Dagleish, M. P., Billington, K. J., Colegrove, K., & Hammond, J. A. (2014). Evidence for a genetic basis of urogenital carcinoma in the wild California sea lion. Proceedings of the Royal Society B: Biological Sciences, 281(1796), Article 20140240. https://doi.org/10.1098/rspb.2014.0240

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title = "Evidence for a genetic basis of urogenital carcinoma in the wild California sea lion",

abstract = "Although neoplasia is a major cause of mortality in humans and domestic animals, it has rarely been described in wildlife species. One of the fewexamples is a highly prevalent urogenital carcinoma in California sea lions (CSLs). Although the aetiology of this carcinoma is clearly multifactorial, inbreeding depression, as estimated using levels of microsatellite multilocus heterozygosity, is identified as predictive for this neoplasia. On further analysis, this relationship appears to be largely driven by one marker, suggesting that a single locus might be associated with the occurrence of this disease in CSLs. In a case–control study, carcinoma was significantly associated with homozygosity at the Pv11 microsatellite locus. Pv11 was mapped to intron 9 of the heparanase 2 gene (HPSE2) locus, a very large gene encoding heparanase 2, which in humans is associated with multiple carcinomas. Correspondingly, immunohistochemical labelling in tissues was present in carcinoma cases within a single homozygous Pv11 genotype. To our knowledge, this is the first report of an individual locus being associated with cancer in any wildlife species. This adds emphasis to the study of HPSE2 in other species, including humans and will guide future studies on this sentinel species that shares much of its diet and environment with humans",

keywords = "Cancer, Heparanase 2 gene, Wildlife, Odds ratio",

author = "Browning, {Helen M.} and Karina Acevedo-Whitehouse and Gulland, {Frances M. D.} and Hall, {Ailsa J.} and Jeanie Finlayson and Dagleish, {Mark P.} and Billington, {Karen J.} and Kathleen Colegrove and Hammond, {John A.}",

note = "This work was funded by a grant from the US National Marine Fisheries Service John H. Prescott Marine Mammal Rescue Assistance grant programme, and H.M.B. was funded by a UK Natural Environment Research Council PhD studentship. J.A.H. was funded by the BBSRC Institute Strategic Programme on Livestock Viral Diseases at The Pirbright Institute.",

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AU - Browning, Helen M.

AU - Acevedo-Whitehouse, Karina

AU - Gulland, Frances M. D.

AU - Hall, Ailsa J.

AU - Finlayson, Jeanie

AU - Dagleish, Mark P.

AU - Billington, Karen J.

AU - Colegrove, Kathleen

AU - Hammond, John A.

N1 - This work was funded by a grant from the US National Marine Fisheries Service John H. Prescott Marine Mammal Rescue Assistance grant programme, and H.M.B. was funded by a UK Natural Environment Research Council PhD studentship. J.A.H. was funded by the BBSRC Institute Strategic Programme on Livestock Viral Diseases at The Pirbright Institute.

PY - 2014/12

Y1 - 2014/12

N2 - Although neoplasia is a major cause of mortality in humans and domestic animals, it has rarely been described in wildlife species. One of the fewexamples is a highly prevalent urogenital carcinoma in California sea lions (CSLs). Although the aetiology of this carcinoma is clearly multifactorial, inbreeding depression, as estimated using levels of microsatellite multilocus heterozygosity, is identified as predictive for this neoplasia. On further analysis, this relationship appears to be largely driven by one marker, suggesting that a single locus might be associated with the occurrence of this disease in CSLs. In a case–control study, carcinoma was significantly associated with homozygosity at the Pv11 microsatellite locus. Pv11 was mapped to intron 9 of the heparanase 2 gene (HPSE2) locus, a very large gene encoding heparanase 2, which in humans is associated with multiple carcinomas. Correspondingly, immunohistochemical labelling in tissues was present in carcinoma cases within a single homozygous Pv11 genotype. To our knowledge, this is the first report of an individual locus being associated with cancer in any wildlife species. This adds emphasis to the study of HPSE2 in other species, including humans and will guide future studies on this sentinel species that shares much of its diet and environment with humans

AB - Although neoplasia is a major cause of mortality in humans and domestic animals, it has rarely been described in wildlife species. One of the fewexamples is a highly prevalent urogenital carcinoma in California sea lions (CSLs). Although the aetiology of this carcinoma is clearly multifactorial, inbreeding depression, as estimated using levels of microsatellite multilocus heterozygosity, is identified as predictive for this neoplasia. On further analysis, this relationship appears to be largely driven by one marker, suggesting that a single locus might be associated with the occurrence of this disease in CSLs. In a case–control study, carcinoma was significantly associated with homozygosity at the Pv11 microsatellite locus. Pv11 was mapped to intron 9 of the heparanase 2 gene (HPSE2) locus, a very large gene encoding heparanase 2, which in humans is associated with multiple carcinomas. Correspondingly, immunohistochemical labelling in tissues was present in carcinoma cases within a single homozygous Pv11 genotype. To our knowledge, this is the first report of an individual locus being associated with cancer in any wildlife species. This adds emphasis to the study of HPSE2 in other species, including humans and will guide future studies on this sentinel species that shares much of its diet and environment with humans

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KW - Wildlife

KW - Odds ratio

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JF - Proceedings of the Royal Society B: Biological Sciences

IS - 1796

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ER -

Evidence for a genetic basis of urogenital carcinoma in the wild California sea lion

Abstract

Keywords

UN SDGs

Access to Document

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Fingerprint

NERC Core Grant: SMRU NERC Core Grant

Cite this

Evidence for a genetic basis of urogenital carcinoma in the wild California sea lion

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Projects

NERC Core Grant: SMRU NERC Core Grant

Cite this