Evaluation of glutathione S-transferase Pi in non-invasive ductal carcinoma of breast

C O Bellamy; D J Harrison

Evaluation of glutathione S-transferase Pi in non-invasive ductal carcinoma of breast

C O Bellamy
, D J Harrison

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Glutathione S-transferase Pi (GST P) has been reported to be a marker of dysplastic lesions. For this reason expression of GST P by intraduct breast carcinoma was evaluated by immunohistochemistry. Thirty-seven of 92 carcinomas (40%) were GST P positive. GST P staining did not correlate with histological variables, c-erbB-2 overexpression or with clinical outcome. The GST P status of recurrences did not correlate with that of the index lesion. There is little evidence that GST P is a useful marker of the potential of intraduct breast carcinoma to become invasive.

Original language	English
Pages (from-to)	183-185
Number of pages	3
Journal	British Journal of Cancer
Volume	69
Issue number	1
Publication status	Published - Jan 1994

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SDG 3 Good Health and Well-being

Keywords

Adult
Aged
Breast neoplasms
Carcinoma in situ
Carcinoma, ductal, breast
Evaluation studies as topic
Female
Follow-up studies
Gene expression
Glutathione Transferase
Humans
Immunohistochemistry
Isoenzymes
Middle aged
Proto-oncogene proteins
Receptor, epidermal growth factor
Receptor, erbB-2

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bellamy1994bjc183
Copyright Macmillan Press Ltd., 1994. Full text is available as a scanned copy of the original print version from Europe PubMed Central PMC1968756
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@article{33292b59152141e8bb63fb4255764c77,

title = "Evaluation of glutathione S-transferase Pi in non-invasive ductal carcinoma of breast",

abstract = "Glutathione S-transferase Pi (GST P) has been reported to be a marker of dysplastic lesions. For this reason expression of GST P by intraduct breast carcinoma was evaluated by immunohistochemistry. Thirty-seven of 92 carcinomas (40\%) were GST P positive. GST P staining did not correlate with histological variables, c-erbB-2 overexpression or with clinical outcome. The GST P status of recurrences did not correlate with that of the index lesion. There is little evidence that GST P is a useful marker of the potential of intraduct breast carcinoma to become invasive.",

keywords = "Adult, Aged, Breast neoplasms, Carcinoma in situ, Carcinoma, ductal, breast, Evaluation studies as topic, Female, Follow-up studies, Gene expression, Glutathione Transferase, Humans, Immunohistochemistry, Isoenzymes, Middle aged, Proto-oncogene proteins, Receptor, epidermal growth factor, Receptor, erbB-2",

author = "Bellamy, \{C O\} and Harrison, \{D J\}",

year = "1994",

month = jan,

language = "English",

volume = "69",

pages = "183--185",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Springer Nature",

number = "1",

}

TY - JOUR

T1 - Evaluation of glutathione S-transferase Pi in non-invasive ductal carcinoma of breast

AU - Bellamy, C O

AU - Harrison, D J

PY - 1994/1

Y1 - 1994/1

N2 - Glutathione S-transferase Pi (GST P) has been reported to be a marker of dysplastic lesions. For this reason expression of GST P by intraduct breast carcinoma was evaluated by immunohistochemistry. Thirty-seven of 92 carcinomas (40%) were GST P positive. GST P staining did not correlate with histological variables, c-erbB-2 overexpression or with clinical outcome. The GST P status of recurrences did not correlate with that of the index lesion. There is little evidence that GST P is a useful marker of the potential of intraduct breast carcinoma to become invasive.

AB - Glutathione S-transferase Pi (GST P) has been reported to be a marker of dysplastic lesions. For this reason expression of GST P by intraduct breast carcinoma was evaluated by immunohistochemistry. Thirty-seven of 92 carcinomas (40%) were GST P positive. GST P staining did not correlate with histological variables, c-erbB-2 overexpression or with clinical outcome. The GST P status of recurrences did not correlate with that of the index lesion. There is little evidence that GST P is a useful marker of the potential of intraduct breast carcinoma to become invasive.

KW - Adult

KW - Aged

KW - Breast neoplasms

KW - Carcinoma in situ

KW - Carcinoma, ductal, breast

KW - Evaluation studies as topic

KW - Female

KW - Follow-up studies

KW - Gene expression

KW - Glutathione Transferase

KW - Humans

KW - Immunohistochemistry

KW - Isoenzymes

KW - Middle aged

KW - Proto-oncogene proteins

KW - Receptor, epidermal growth factor

KW - Receptor, erbB-2

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968756/

M3 - Article

SN - 0007-0920

VL - 69

SP - 183

EP - 185

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 1

ER -

Evaluation of glutathione S-transferase Pi in non-invasive ductal carcinoma of breast

Abstract

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