Evaluation of (2S,4S)/(2R,4R) and (2S,4R)/(2R,4S) 6,6-N,N-dimethyl-2-methyl-2-oxo-1,3-dioxa-4-hexadecyl-6,aza-2-phosphacyc looctane bromide as inhibitors for protein kinase C, carnitine octanoyltransferase, and carnitine palmitoyltransferase

G. Kumaravel; N. Nic a' Bháird; F. R. Fronczek; R. R. Ramsay; C. L. Ashendel; R. D. Gandour

doi:10.1016/S0960-894X(01)80256-0

Evaluation of (2S,4S)/(2R,4R) and (2S,4R)/(2R,4S) 6,6-N,N-dimethyl-2-methyl-2-oxo-1,3-dioxa-4-hexadecyl-6,aza-2-phosphacyc looctane bromide as inhibitors for protein kinase C, carnitine octanoyltransferase, and carnitine palmitoyltransferase

G. Kumaravel^*, N. Nic a' Bháird, F. R. Fronczek, R. R. Ramsay, C. L. Ashendel, R. D. Gandour

^*Corresponding author for this work

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Abstract

(2S,4S)/(2R,4R) and (2S,4R)/(2R,4S) 6,6-N,N-dimethyl-2-methyl-2-oxo-1,3-dioxa-4-hexadecyl-6-aza-2-phosphacyc looctane bromide strongly inhibited protein kinase C and moderately inhibited carnitine octanoyltransferase and carnitine palmitoyltransferase.

Original language	English
Pages (from-to)	883-886
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	7
DOIs	https://doi.org/10.1016/S0960-894X(01)80256-0
Publication status	Published - 1 Jan 1994

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Kumaravel, G., Nic a' Bháird, N., Fronczek, F. R., Ramsay, R. R., Ashendel, C. L., & Gandour, R. D. (1994). Evaluation of (2S,4S)/(2R,4R) and (2S,4R)/(2R,4S) 6,6-N,N-dimethyl-2-methyl-2-oxo-1,3-dioxa-4-hexadecyl-6,aza-2-phosphacyc looctane bromide as inhibitors for protein kinase C, carnitine octanoyltransferase, and carnitine palmitoyltransferase. Bioorganic and Medicinal Chemistry Letters, 4(7), 883-886. https://doi.org/10.1016/S0960-894X(01)80256-0

Kumaravel, G. ; Nic a' Bháird, N. ; Fronczek, F. R. et al. / Evaluation of (2S,4S)/(2R,4R) and (2S,4R)/(2R,4S) 6,6-N,N-dimethyl-2-methyl-2-oxo-1,3-dioxa-4-hexadecyl-6,aza-2-phosphacyc looctane bromide as inhibitors for protein kinase C, carnitine octanoyltransferase, and carnitine palmitoyltransferase. In: Bioorganic and Medicinal Chemistry Letters. 1994 ; Vol. 4, No. 7. pp. 883-886.

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title = "Evaluation of (2S,4S)/(2R,4R) and (2S,4R)/(2R,4S) 6,6-N,N-dimethyl-2-methyl-2-oxo-1,3-dioxa-4-hexadecyl-6,aza-2-phosphacyc looctane bromide as inhibitors for protein kinase C, carnitine octanoyltransferase, and carnitine palmitoyltransferase",

abstract = "(2S,4S)/(2R,4R) and (2S,4R)/(2R,4S) 6,6-N,N-dimethyl-2-methyl-2-oxo-1,3-dioxa-4-hexadecyl-6-aza-2-phosphacyc looctane bromide strongly inhibited protein kinase C and moderately inhibited carnitine octanoyltransferase and carnitine palmitoyltransferase.",

author = "G. Kumaravel and {Nic a' Bh{\'a}ird}, N. and Fronczek, {F. R.} and Ramsay, {R. R.} and Ashendel, {C. L.} and Gandour, {R. D.}",

year = "1994",

month = jan,

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doi = "10.1016/S0960-894X(01)80256-0",

language = "English",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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Kumaravel, G, Nic a' Bháird, N, Fronczek, FR, Ramsay, RR, Ashendel, CL & Gandour, RD 1994, 'Evaluation of (2S,4S)/(2R,4R) and (2S,4R)/(2R,4S) 6,6-N,N-dimethyl-2-methyl-2-oxo-1,3-dioxa-4-hexadecyl-6,aza-2-phosphacyc looctane bromide as inhibitors for protein kinase C, carnitine octanoyltransferase, and carnitine palmitoyltransferase', Bioorganic and Medicinal Chemistry Letters, vol. 4, no. 7, pp. 883-886. https://doi.org/10.1016/S0960-894X(01)80256-0

Evaluation of (2S,4S)/(2R,4R) and (2S,4R)/(2R,4S) 6,6-N,N-dimethyl-2-methyl-2-oxo-1,3-dioxa-4-hexadecyl-6,aza-2-phosphacyc looctane bromide as inhibitors for protein kinase C, carnitine octanoyltransferase, and carnitine palmitoyltransferase. / Kumaravel, G.; Nic a' Bháird, N.; Fronczek, F. R. et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 4, No. 7, 01.01.1994, p. 883-886.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

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AU - Kumaravel, G.

AU - Nic a' Bháird, N.

AU - Fronczek, F. R.

AU - Ramsay, R. R.

AU - Ashendel, C. L.

AU - Gandour, R. D.

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Kumaravel G, Nic a' Bháird N, Fronczek FR, Ramsay RR, Ashendel CL, Gandour RD. Evaluation of (2S,4S)/(2R,4R) and (2S,4R)/(2R,4S) 6,6-N,N-dimethyl-2-methyl-2-oxo-1,3-dioxa-4-hexadecyl-6,aza-2-phosphacyc looctane bromide as inhibitors for protein kinase C, carnitine octanoyltransferase, and carnitine palmitoyltransferase. Bioorganic and Medicinal Chemistry Letters. 1994 Jan 1;4(7):883-886. doi: 10.1016/S0960-894X(01)80256-0

Evaluation of (2S,4S)/(2R,4R) and (2S,4R)/(2R,4S) 6,6-N,N-dimethyl-2-methyl-2-oxo-1,3-dioxa-4-hexadecyl-6,aza-2-phosphacyc looctane bromide as inhibitors for protein kinase C, carnitine octanoyltransferase, and carnitine palmitoyltransferase

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