EULAR study group on 'MHC-I-opathy': identifying disease-overarching mechanisms across disciplines and borders

Jonas Jw Kuiper, Jörg C Prinz, Efstratios Stratikos, Piotr Kuśnierczyk, Akiko Arakawa, Sebastian Springer, Dillon Mintoff, Ivan Padjen, Russka Shumnalieva, Seçil Vural, Ina Kötter, Marleen G van de Sande, Ayşe Boyvat, Joke H de Boer, George Bertsias, Niek de Vries, Charlotte Lm Krieckaert, Inês Leal, Nataša Vidovič Valentinčič, Ilknur Tugal-TutkunHanane El Khaldi Ahanach, Félicie Costantino, Simon Glatigny, Danijela Mrazovac Zimak, Fabian Lötscher, Floor G Kerstens, Marija Bakula, Elsa Viera Sousa, Peter Böhm, Kees Bosman, Tony J Kenna, Simon J Powis, Maxime Breban, Ahmet Gul, John Bowes, Rik Ju Lories, Johannes Nowatzky, Gerrit Jan Wolbink, Dennis G McGonagle, Franktien Turkstra*, EULAR studygroup MHC-I-opathies

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Downloads (Pure)

Abstract

The 'MHC-I (major histocompatibility complex class I)-opathy' concept describes a family of inflammatory conditions with overlapping clinical manifestations and a strong genetic link to the MHC-I antigen presentation pathway. Classical MHC-I-opathies such as spondyloarthritis, Behçet's disease, psoriasis and birdshot uveitis are widely recognised for their strong association with certain MHC-I alleles and gene variants of the antigen processing aminopeptidases ERAP1 and ERAP2 that implicates altered MHC-I peptide presentation to CD8+T cells in the pathogenesis. Progress in understanding the cause and treatment of these disorders is hampered by patient phenotypic heterogeneity and lack of systematic investigation of the MHC-I pathway.Here, we discuss new insights into the biology of MHC-I-opathies that strongly advocate for disease-overarching and integrated molecular and clinical investigation to decipher underlying disease mechanisms. Because this requires transformative multidisciplinary collaboration, we introduce the EULAR study group on MHC-I-opathies to unite clinical expertise in rheumatology, dermatology and ophthalmology, with fundamental and translational researchers from multiple disciplines such as immunology, genomics and proteomics, alongside patient partners. We prioritise standardisation of disease phenotypes and scientific nomenclature and propose interdisciplinary genetic and translational studies to exploit emerging therapeutic strategies to understand MHC-I-mediated disease mechanisms. These collaborative efforts are required to address outstanding questions in the etiopathogenesis of MHC-I-opathies towards improving patient treatment and prognostication.

Original languageEnglish
Pages (from-to)887-896
Number of pages10
JournalAnnals of the Rheumatic Diseases
Volume82
Issue number7
Early online date12 Jun 2023
DOIs
Publication statusPublished - 1 Jul 2023

Fingerprint

Dive into the research topics of 'EULAR study group on 'MHC-I-opathy': identifying disease-overarching mechanisms across disciplines and borders'. Together they form a unique fingerprint.

Cite this