EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration

J. K. Field; T. Liloglou; A. Niaz; J. Bryan; J. R. Gosney; T. Giles; C. Brambilla; E. Brambilla; A. Vesin; J-F. Timsit; P. Hainaut; Y. Martinet; J. M. Vignaud; F. B. Thunnissen; C. Prinsen; P. J. Snijders; E. F. Smit; G. Sozzi; L. Roz; A. Risch; H. D. Becker; J. S. Elborn; N. D. Magee; L. M. Montuenga; M. J. Pajares; M. D. Lozano; K. J. O'Byrne; D. J. Harrison; J. Niklinski; A. Cassidy; EUELC Collaborators

doi:10.1183/09031936.00077809

EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration

J. K. Field, T. Liloglou, A. Niaz, J. Bryan, J. R. Gosney, T. Giles, C. Brambilla, E. Brambilla, A. Vesin, J-F. Timsit, P. Hainaut, Y. Martinet, J. M. Vignaud, F. B. Thunnissen, C. Prinsen, P. J. Snijders, E. F. Smit, G. Sozzi, L. Roz, A. RischH. D. Becker, J. S. Elborn, N. D. Magee, L. M. Montuenga, M. J. Pajares, M. D. Lozano, K. J. O'Byrne, D. J. Harrison, J. Niklinski, A. Cassidy, EUELC Collaborators

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The European Early Lung Cancer (EUELC) project alms to determine if specific genetic alterations occurring in lung carcinogenesis are detectable in the respiratory epithelium. In order to pursue this objective, nonsmall cell lung cancer (NSCLC) patients with a very high risk of developing progressive lung cancer were recruited from 12 centres in eight European countries: France, Germany, southern Ireland, Italy, the Netherlands, Poland, Spain and the UK. In addition, NSCLC patients were followed up every 6 months for 36 months. A European Bronchial Tissue Bank was set up at the University of Liverpool (Liverpool, UK) to optimise the use of biological specimens.

The molecular-pathological investigations were subdivided into specific work packages that were delivered by EUELC Partners. The work packages encompassed mutational analysis, genetic instability, methylation profiling, expression profiling utilising immunohistochemistry and chip-based technologies, as well as in-depth analysis of FHIT and RAR beta genes, the telomerase catalytic subunit hTERT and genotyping of susceptibility genes in specific pathways.

The EUELC project engendered a tremendous collaborative effort, and it enabled the EUELC Partners to establish protocols for assessing molecular biomarkers in early lung cancer with the view to using such biomarkers for early diagnosis and as intermediate end-points in future chemopreventive programmes.

Original language	English
Pages (from-to)	1477-1486
Number of pages	10
Journal	European Respiratory Journal
Volume	34
Issue number	6
DOIs	https://doi.org/10.1183/09031936.00077809
Publication status	Published - Dec 2009

Keywords

Pulmonary and Respiratory Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Field, J. K., Liloglou, T., Niaz, A., Bryan, J., Gosney, J. R., Giles, T., Brambilla, C., Brambilla, E., Vesin, A., Timsit, J.-F., Hainaut, P., Martinet, Y., Vignaud, J. M., Thunnissen, F. B., Prinsen, C., Snijders, P. J., Smit, E. F., Sozzi, G., Roz, L., ... Collaborators, EUELC. (2009). EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration. European Respiratory Journal, 34(6), 1477-1486. https://doi.org/10.1183/09031936.00077809

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title = "EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration",

abstract = "The European Early Lung Cancer (EUELC) project alms to determine if specific genetic alterations occurring in lung carcinogenesis are detectable in the respiratory epithelium. In order to pursue this objective, nonsmall cell lung cancer (NSCLC) patients with a very high risk of developing progressive lung cancer were recruited from 12 centres in eight European countries: France, Germany, southern Ireland, Italy, the Netherlands, Poland, Spain and the UK. In addition, NSCLC patients were followed up every 6 months for 36 months. A European Bronchial Tissue Bank was set up at the University of Liverpool (Liverpool, UK) to optimise the use of biological specimens.The molecular-pathological investigations were subdivided into specific work packages that were delivered by EUELC Partners. The work packages encompassed mutational analysis, genetic instability, methylation profiling, expression profiling utilising immunohistochemistry and chip-based technologies, as well as in-depth analysis of FHIT and RAR beta genes, the telomerase catalytic subunit hTERT and genotyping of susceptibility genes in specific pathways.The EUELC project engendered a tremendous collaborative effort, and it enabled the EUELC Partners to establish protocols for assessing molecular biomarkers in early lung cancer with the view to using such biomarkers for early diagnosis and as intermediate end-points in future chemopreventive programmes.",

keywords = "Pulmonary and Respiratory Medicine",

author = "Field, {J. K.} and T. Liloglou and A. Niaz and J. Bryan and Gosney, {J. R.} and T. Giles and C. Brambilla and E. Brambilla and A. Vesin and J-F. Timsit and P. Hainaut and Y. Martinet and Vignaud, {J. M.} and Thunnissen, {F. B.} and C. Prinsen and Snijders, {P. J.} and Smit, {E. F.} and G. Sozzi and L. Roz and A. Risch and Becker, {H. D.} and Elborn, {J. S.} and Magee, {N. D.} and Montuenga, {L. M.} and Pajares, {M. J.} and Lozano, {M. D.} and O'Byrne, {K. J.} and Harrison, {D. J.} and J. Niklinski and A. Cassidy and EUELC Collaborators",

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Field, JK, Liloglou, T, Niaz, A, Bryan, J, Gosney, JR, Giles, T, Brambilla, C, Brambilla, E, Vesin, A, Timsit, J-F, Hainaut, P, Martinet, Y, Vignaud, JM, Thunnissen, FB, Prinsen, C, Snijders, PJ, Smit, EF, Sozzi, G, Roz, L, Risch, A, Becker, HD, Elborn, JS, Magee, ND, Montuenga, LM, Pajares, MJ, Lozano, MD, O'Byrne, KJ, Harrison, DJ, Niklinski, J, Cassidy, A & Collaborators, EUELC 2009, 'EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration', European Respiratory Journal, vol. 34, no. 6, pp. 1477-1486. https://doi.org/10.1183/09031936.00077809

TY - JOUR

T1 - EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration

AU - Field, J. K.

AU - Liloglou, T.

AU - Niaz, A.

AU - Bryan, J.

AU - Gosney, J. R.

AU - Giles, T.

AU - Brambilla, C.

AU - Brambilla, E.

AU - Vesin, A.

AU - Timsit, J-F.

AU - Hainaut, P.

AU - Martinet, Y.

AU - Vignaud, J. M.

AU - Thunnissen, F. B.

AU - Prinsen, C.

AU - Snijders, P. J.

AU - Smit, E. F.

AU - Sozzi, G.

AU - Roz, L.

AU - Risch, A.

AU - Becker, H. D.

AU - Elborn, J. S.

AU - Magee, N. D.

AU - Montuenga, L. M.

AU - Pajares, M. J.

AU - Lozano, M. D.

AU - O'Byrne, K. J.

AU - Harrison, D. J.

AU - Niklinski, J.

AU - Cassidy, A.

AU - Collaborators, EUELC

N1 - M1 - Article

PY - 2009/12

Y1 - 2009/12

N2 - The European Early Lung Cancer (EUELC) project alms to determine if specific genetic alterations occurring in lung carcinogenesis are detectable in the respiratory epithelium. In order to pursue this objective, nonsmall cell lung cancer (NSCLC) patients with a very high risk of developing progressive lung cancer were recruited from 12 centres in eight European countries: France, Germany, southern Ireland, Italy, the Netherlands, Poland, Spain and the UK. In addition, NSCLC patients were followed up every 6 months for 36 months. A European Bronchial Tissue Bank was set up at the University of Liverpool (Liverpool, UK) to optimise the use of biological specimens.The molecular-pathological investigations were subdivided into specific work packages that were delivered by EUELC Partners. The work packages encompassed mutational analysis, genetic instability, methylation profiling, expression profiling utilising immunohistochemistry and chip-based technologies, as well as in-depth analysis of FHIT and RAR beta genes, the telomerase catalytic subunit hTERT and genotyping of susceptibility genes in specific pathways.The EUELC project engendered a tremendous collaborative effort, and it enabled the EUELC Partners to establish protocols for assessing molecular biomarkers in early lung cancer with the view to using such biomarkers for early diagnosis and as intermediate end-points in future chemopreventive programmes.

AB - The European Early Lung Cancer (EUELC) project alms to determine if specific genetic alterations occurring in lung carcinogenesis are detectable in the respiratory epithelium. In order to pursue this objective, nonsmall cell lung cancer (NSCLC) patients with a very high risk of developing progressive lung cancer were recruited from 12 centres in eight European countries: France, Germany, southern Ireland, Italy, the Netherlands, Poland, Spain and the UK. In addition, NSCLC patients were followed up every 6 months for 36 months. A European Bronchial Tissue Bank was set up at the University of Liverpool (Liverpool, UK) to optimise the use of biological specimens.The molecular-pathological investigations were subdivided into specific work packages that were delivered by EUELC Partners. The work packages encompassed mutational analysis, genetic instability, methylation profiling, expression profiling utilising immunohistochemistry and chip-based technologies, as well as in-depth analysis of FHIT and RAR beta genes, the telomerase catalytic subunit hTERT and genotyping of susceptibility genes in specific pathways.The EUELC project engendered a tremendous collaborative effort, and it enabled the EUELC Partners to establish protocols for assessing molecular biomarkers in early lung cancer with the view to using such biomarkers for early diagnosis and as intermediate end-points in future chemopreventive programmes.

KW - Pulmonary and Respiratory Medicine

U2 - 10.1183/09031936.00077809

DO - 10.1183/09031936.00077809

M3 - Article

SN - 0903-1936

VL - 34

SP - 1477

EP - 1486

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 6

ER -

EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration

Abstract

Keywords

UN SDGs

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