Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: a new approach

Holly B Posner, Stefan Cano, Maria C Carrillo, Ola Selnes, Yaakov Stern, Ronald G Thomas, John Zajicek, Jeremy Hobart, Alzheimer’s Disease Neuroimaging Initiative

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The Alzheimer's disease (AD) Cognitive Behavior Section (ADAS-Cog) is the most commonly used cognitive test in clinical trials of AD. Recent trials have focused on people earlier in the course of disease; however, there are concerns about using the ADAS-Cog at this crucial stage. Using data from the Alzheimer's disease Neuroimaging Initiative study, we used a range of traditional psychometric tests to evaluate those concerns. This issue of Alzheimer's & Dementia includes two articles that evaluate the ADAS-Cog. These articles report evaluations using two psychometric approaches: traditional methods and new methods. In this review, we provide accompanying background information to this program of research.

Original languageEnglish
Pages (from-to)S56-60
JournalAlzheimer's and Dementia
Volume9
Issue number1 Suppl
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Alzheimer Disease
  • Clinical Trials as Topic
  • Humans
  • Neuropsychological Tests
  • Psychometrics
  • Research Design

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