Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: a new approach

Holly B Posner; Stefan Cano; Maria C Carrillo; Ola Selnes; Yaakov Stern; Ronald G Thomas; John Zajicek; Jeremy Hobart; Alzheimer’s Disease Neuroimaging Initiative

doi:10.1016/j.jalz.2012.10.008

Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: a new approach

Holly B Posner, Stefan Cano, Maria C Carrillo, Ola Selnes, Yaakov Stern, Ronald G Thomas, John Zajicek, Jeremy Hobart, Alzheimer’s Disease Neuroimaging Initiative

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The Alzheimer's disease (AD) Cognitive Behavior Section (ADAS-Cog) is the most commonly used cognitive test in clinical trials of AD. Recent trials have focused on people earlier in the course of disease; however, there are concerns about using the ADAS-Cog at this crucial stage. Using data from the Alzheimer's disease Neuroimaging Initiative study, we used a range of traditional psychometric tests to evaluate those concerns. This issue of Alzheimer's & Dementia includes two articles that evaluate the ADAS-Cog. These articles report evaluations using two psychometric approaches: traditional methods and new methods. In this review, we provide accompanying background information to this program of research.

Original language	English
Pages (from-to)	S56-60
Journal	Alzheimer's and Dementia
Volume	9
Issue number	1 Suppl
DOIs	https://doi.org/10.1016/j.jalz.2012.10.008
Publication status	Published - Feb 2013

Keywords

Alzheimer Disease
Clinical Trials as Topic
Humans
Neuropsychological Tests
Psychometrics
Research Design

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10.1016/j.jalz.2012.10.008

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Posner, H. B., Cano, S., Carrillo, M. C., Selnes, O., Stern, Y., Thomas, R. G., Zajicek, J., Hobart, J., & Alzheimer’s Disease Neuroimaging Initiative (2013). Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: a new approach. Alzheimer's and Dementia, 9(1 Suppl), S56-60. https://doi.org/10.1016/j.jalz.2012.10.008

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abstract = "The Alzheimer's disease (AD) Cognitive Behavior Section (ADAS-Cog) is the most commonly used cognitive test in clinical trials of AD. Recent trials have focused on people earlier in the course of disease; however, there are concerns about using the ADAS-Cog at this crucial stage. Using data from the Alzheimer's disease Neuroimaging Initiative study, we used a range of traditional psychometric tests to evaluate those concerns. This issue of Alzheimer's & Dementia includes two articles that evaluate the ADAS-Cog. These articles report evaluations using two psychometric approaches: traditional methods and new methods. In this review, we provide accompanying background information to this program of research.",

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author = "Posner, {Holly B} and Stefan Cano and Carrillo, {Maria C} and Ola Selnes and Yaakov Stern and Thomas, {Ronald G} and John Zajicek and Jeremy Hobart and {Alzheimer{\textquoteright}s Disease Neuroimaging Initiative}",

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Posner, HB, Cano, S, Carrillo, MC, Selnes, O, Stern, Y, Thomas, RG, Zajicek, J, Hobart, J & Alzheimer’s Disease Neuroimaging Initiative 2013, 'Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: a new approach', Alzheimer's and Dementia, vol. 9, no. 1 Suppl, pp. S56-60. https://doi.org/10.1016/j.jalz.2012.10.008

TY - JOUR

T1 - Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors

T2 - a new approach

AU - Posner, Holly B

AU - Cano, Stefan

AU - Carrillo, Maria C

AU - Selnes, Ola

AU - Stern, Yaakov

AU - Thomas, Ronald G

AU - Zajicek, John

AU - Hobart, Jeremy

AU - Alzheimer’s Disease Neuroimaging Initiative

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AB - The Alzheimer's disease (AD) Cognitive Behavior Section (ADAS-Cog) is the most commonly used cognitive test in clinical trials of AD. Recent trials have focused on people earlier in the course of disease; however, there are concerns about using the ADAS-Cog at this crucial stage. Using data from the Alzheimer's disease Neuroimaging Initiative study, we used a range of traditional psychometric tests to evaluate those concerns. This issue of Alzheimer's & Dementia includes two articles that evaluate the ADAS-Cog. These articles report evaluations using two psychometric approaches: traditional methods and new methods. In this review, we provide accompanying background information to this program of research.

KW - Alzheimer Disease

KW - Clinical Trials as Topic

KW - Humans

KW - Neuropsychological Tests

KW - Psychometrics

KW - Research Design

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DO - 10.1016/j.jalz.2012.10.008

M3 - Article

C2 - 23391006

SN - 1552-5260

VL - 9

SP - S56-60

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 1 Suppl

ER -

Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: a new approach

Abstract

Keywords

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