Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR

Victor H. Villar, Tra Ly Nguyen, Silvia Terés, Clément Bodineau, Raúl V. Durán*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

A master promoter of cell growth, mammalian target of rapamycin (mTOR) is upregulated in a large percentage of cancer cells. Still, targeting mTOR using rapamycin has a limited outcome in patients. Our recent results highlight the additional role of mTOR as a tumor suppressor, explaining these modest results in the clinic.

Original languageEnglish
Article numbere1297284
JournalMolecular and Cellular Oncology
Volume4
Issue number3
DOIs
Publication statusPublished - 4 May 2017

Keywords

  • autophagy
  • cancer metabolism
  • glutamoptosis
  • mTORC1
  • rapamycin
  • α-ketoglutarate

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