@article{213efbfd565549549dd57f8fc377050a,
title = "Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR",
abstract = "A master promoter of cell growth, mammalian target of rapamycin (mTOR) is upregulated in a large percentage of cancer cells. Still, targeting mTOR using rapamycin has a limited outcome in patients. Our recent results highlight the additional role of mTOR as a tumor suppressor, explaining these modest results in the clinic.",
keywords = "autophagy, cancer metabolism, glutamoptosis, mTORC1, rapamycin, α-ketoglutarate",
author = "Villar, {Victor H.} and Nguyen, {Tra Ly} and Silvia Ter{\'e}s and Cl{\'e}ment Bodineau and Dur{\'a}n, {Ra{\'u}l V.}",
note = "Funding Information: This work was supported by funds from the following institutions: Institut National de la Sant{\'e}et de la Recherche M{\'e}dicale - INSERM, Fondation pour la Recherche M{\'e}dicale, Conseil R{\'e}gional d{\textquoteright}Aquitaine, Fondation ARC pour la Recherche sur le Cancer, SIRIC-BRIO, and Institut Europ{\'e}en de Chimie et Biologie. Publisher Copyright: {\textcopyright} 2017, {\textcopyright} 2017 The Author(s). Published with license by Taylor & Francis Group, LLC. {\textcopyright} 2017, {\textcopyright} Victor H. Villar, Tra Ly Nguyen, Silvia Ter{\'e}s, Cl{\'e}ment Bodineau, and Ra{\'u}l V. Dur{\'a}n.",
year = "2017",
month = may,
day = "4",
doi = "10.1080/23723556.2017.1297284",
language = "English",
volume = "4",
journal = "Molecular and Cellular Oncology",
issn = "2372-3556",
publisher = "Taylor and Francis",
number = "3",
}
