Enhanced Cell Transfection using sub-wavelength focused optical eigenmode beams

Xanthi Tsampoula, Michael Mazilu, Tom Vettenburg, Frank J Gunn-Moore, Kishan Dholakia

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

We show that superoscillating light fields, created using the method of optical eigenmodes, enable more efficient multiphoton-mediated cell transfection. Chinese hamster ovary cells are transfected with a plasmid and exhibit expression of DsRed-Mito in the mitochondria. We demonstrate an efficiency improvement of 35% compared to the diffraction-limited spot. This opens up new vistas for nanoscale localized cell transfection. © 2013 Chinese Laser Press
Original languageEnglish
Pages (from-to)42-46
Number of pages5
JournalPhotonics Research
Volume1
Issue number1
DOIs
Publication statusPublished - 11 Jun 2013

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