Abstract
Waveguide confined Raman spectroscopy (WCRS) incorporates a fibre based Raman detection system in a microfluidic platform enabling the spectroscopic detection of analyte. It offers the possibility to develop portable, alignment free devices for bio-analyte sensing with minimal sample preparation. Ultimate sensitivity is limited by the fibre auto-fluorescence background. Here we report enhanced bio-analyte detection sensitivity by combining WCRS with continuous wavelength modulation technique. We used urea as a model analyte and the modulation parameters have been optimized to maximize the sensitivity of the device.
| Original language | English |
|---|---|
| Number of pages | 5 |
| Journal | Journal of Biophotonics |
| Early online date | 24 Jan 2011 |
| DOIs | |
| Publication status | Published - 2011 |
Keywords
- raman spectroscopy
- microfluidics
- analyte detection
- fluorescent suppression
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Dive into the research topics of 'Enhanced bioanalyte detection in waveguide confined Raman spectroscopy using wavelength modulation'. Together they form a unique fingerprint.Projects
- 1 Finished
-
EPSRC Postdoctoral Research Fellowship: EPSRC Postdoctoral Fellowship
De Luca, A. (PI)
1/10/10 → 29/02/12
Project: Fellowship
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