Enhanced bioanalyte detection in waveguide confined Raman spectroscopy using wavelength modulation

Praveen Cheriyan Ashok, Anna Chiara De Luca, Michael Mazilu, Kishan Dholakia

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Waveguide confined Raman spectroscopy (WCRS) incorporates a fibre based Raman detection system in a microfluidic platform enabling the spectroscopic detection of analyte. It offers the possibility to develop portable, alignment free devices for bio-analyte sensing with minimal sample preparation. Ultimate sensitivity is limited by the fibre auto-fluorescence background. Here we report enhanced bio-analyte detection sensitivity by combining WCRS with continuous wavelength modulation technique. We used urea as a model analyte and the modulation parameters have been optimized to maximize the sensitivity of the device.
Original languageEnglish
Number of pages5
JournalJournal of Biophotonics
Early online date24 Jan 2011
DOIs
Publication statusPublished - 2011

Keywords

  • raman spectroscopy
  • microfluidics
  • analyte detection
  • fluorescent suppression

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