Enhanced bioanalyte detection in waveguide confined Raman spectroscopy using wavelength modulation

Praveen Cheriyan Ashok; Anna Chiara De Luca; Michael Mazilu; Kishan Dholakia

doi:10.1002/jbio.201000107

Enhanced bioanalyte detection in waveguide confined Raman spectroscopy using wavelength modulation

Praveen Cheriyan Ashok, Anna Chiara De Luca, Michael Mazilu, Kishan Dholakia

Research output: Contribution to journal › Article › peer-review

Abstract

Waveguide confined Raman spectroscopy (WCRS) incorporates a fibre based Raman detection system in a microfluidic platform enabling the spectroscopic detection of analyte. It offers the possibility to develop portable, alignment free devices for bio-analyte sensing with minimal sample preparation. Ultimate sensitivity is limited by the fibre auto-fluorescence background. Here we report enhanced bio-analyte detection sensitivity by combining WCRS with continuous wavelength modulation technique. We used urea as a model analyte and the modulation parameters have been optimized to maximize the sensitivity of the device.

Original language	English
Number of pages	5
Journal	Journal of Biophotonics
Early online date	24 Jan 2011
DOIs	https://doi.org/10.1002/jbio.201000107
Publication status	Published - 2011

Keywords

raman spectroscopy
microfluidics
analyte detection
fluorescent suppression

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10.1002/jbio.201000107

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title = "Enhanced bioanalyte detection in waveguide confined Raman spectroscopy using wavelength modulation",

abstract = "Waveguide confined Raman spectroscopy (WCRS) incorporates a fibre based Raman detection system in a microfluidic platform enabling the spectroscopic detection of analyte. It offers the possibility to develop portable, alignment free devices for bio-analyte sensing with minimal sample preparation. Ultimate sensitivity is limited by the fibre auto-fluorescence background. Here we report enhanced bio-analyte detection sensitivity by combining WCRS with continuous wavelength modulation technique. We used urea as a model analyte and the modulation parameters have been optimized to maximize the sensitivity of the device. ",

keywords = "raman spectroscopy, microfluidics, analyte detection , fluorescent suppression",

author = "Ashok, {Praveen Cheriyan} and {De Luca}, {Anna Chiara} and Michael Mazilu and Kishan Dholakia",

year = "2011",

doi = "10.1002/jbio.201000107",

language = "English",

journal = "Journal of Biophotonics",

issn = "1864-063X",

publisher = "Wiley-Blackwell",

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T1 - Enhanced bioanalyte detection in waveguide confined Raman spectroscopy using wavelength modulation

AU - Ashok, Praveen Cheriyan

AU - De Luca, Anna Chiara

AU - Mazilu, Michael

AU - Dholakia, Kishan

PY - 2011

Y1 - 2011

N2 - Waveguide confined Raman spectroscopy (WCRS) incorporates a fibre based Raman detection system in a microfluidic platform enabling the spectroscopic detection of analyte. It offers the possibility to develop portable, alignment free devices for bio-analyte sensing with minimal sample preparation. Ultimate sensitivity is limited by the fibre auto-fluorescence background. Here we report enhanced bio-analyte detection sensitivity by combining WCRS with continuous wavelength modulation technique. We used urea as a model analyte and the modulation parameters have been optimized to maximize the sensitivity of the device.

AB - Waveguide confined Raman spectroscopy (WCRS) incorporates a fibre based Raman detection system in a microfluidic platform enabling the spectroscopic detection of analyte. It offers the possibility to develop portable, alignment free devices for bio-analyte sensing with minimal sample preparation. Ultimate sensitivity is limited by the fibre auto-fluorescence background. Here we report enhanced bio-analyte detection sensitivity by combining WCRS with continuous wavelength modulation technique. We used urea as a model analyte and the modulation parameters have been optimized to maximize the sensitivity of the device.

KW - raman spectroscopy

KW - microfluidics

KW - analyte detection

KW - fluorescent suppression

UR - http://onlinelibrary.wiley.com/doi/10.1002/jbio.201000107/abstract;jsessionid=D30425E1592DE9ABC6F01AA5355E1635.d02t01

U2 - 10.1002/jbio.201000107

DO - 10.1002/jbio.201000107

M3 - Article

SN - 1864-063X

JO - Journal of Biophotonics

JF - Journal of Biophotonics

ER -

Enhanced bioanalyte detection in waveguide confined Raman spectroscopy using wavelength modulation

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Keywords

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EPSRC Postdoctoral Research Fellowship: EPSRC Postdoctoral Fellowship

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Enhanced bioanalyte detection in waveguide confined Raman spectroscopy using wavelength modulation

Abstract

Keywords

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Projects

EPSRC Postdoctoral Research Fellowship: EPSRC Postdoctoral Fellowship

Cite this