Projects per year
Abstract
Organofluorine compounds play an important role in medicinal chemistry, where they are responsible for up to 15% of the pharmaceutical products oil the market, While natural products are Valuable sources of new chemical entities, natural fluorinated Molecules are extremely rare and the pharmaceutical industry has not benefited from a microbial source of this class of compounds. Streptomyces cattleya is all unusual bacterium in that it elaborates fluoroacetate and the amino acid 4-fluorothreonine. The discovery in 2002 of the fluorination enzyme FIA responsible for C-F bond formation in S. cattleya. and its subsequent characterization, opened Lit) for the first time the prospect Of genetically engineering fluorometabolite production front fluoride ion in host organisms. As a proof of principle, we report here the induced production of fluorosalinosporamide by replacing the chlorinase gene salL from Solinispora tropica with the fluorinase gene flA.
Original language | English |
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Pages (from-to) | 378-382 |
Number of pages | 5 |
Journal | Journal of Natural Products |
Volume | 73 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2010 |
Keywords
- INHIBITORS
- ANTIPROTEALIDE
- STREPTOMYCES-CATTLEYA
- MECHANISM
- BIOSYNTHESIS
- NATURAL-PRODUCT
- CHLORINASE
- PROTEASOME
- HALOGENATION
- SALINOSPORAMIDE-A
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Dive into the research topics of 'Engineering Fluorometabolite Production: Fluorinase Expression in Salinispora tropica Yields Fluorosalinosporamide'. Together they form a unique fingerprint.Projects
- 1 Finished
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Enzymatic fluorination in Streptomyces: Enzymatic Fluorination in Streptomyces cattleya. Setting a framework for biotechnological development
O'Hagan, D. (PI) & Naismith, J. (CoI)
1/01/08 → 31/05/12
Project: Standard