Projects per year
Organofluorine compounds play an important role in medicinal chemistry, where they are responsible for up to 15% of the pharmaceutical products oil the market, While natural products are Valuable sources of new chemical entities, natural fluorinated Molecules are extremely rare and the pharmaceutical industry has not benefited from a microbial source of this class of compounds. Streptomyces cattleya is all unusual bacterium in that it elaborates fluoroacetate and the amino acid 4-fluorothreonine. The discovery in 2002 of the fluorination enzyme FIA responsible for C-F bond formation in S. cattleya. and its subsequent characterization, opened Lit) for the first time the prospect Of genetically engineering fluorometabolite production front fluoride ion in host organisms. As a proof of principle, we report here the induced production of fluorosalinosporamide by replacing the chlorinase gene salL from Solinispora tropica with the fluorinase gene flA.
FingerprintDive into the research topics of 'Engineering Fluorometabolite Production: Fluorinase Expression in Salinispora tropica Yields Fluorosalinosporamide'. Together they form a unique fingerprint.
- 1 Finished
Enzymatic fluorination in Streptomyces: Enzymatic Fluorination in Streptomyces cattleya. Setting a framework for biotechnological development
O'Hagan, D. & Naismith, J.
1/01/08 → 31/05/12