Engineered Biocompatible Nanoparticles for in Vivo Imaging Applications

Shu Chen; Lijun Wang; Suzanne L. Duce; Stuart Brown; Stephen Lee; Andreas Melzer; Sir Alfred Cuschieri; Pascal Andre

doi:10.1021/ja106543j

Engineered Biocompatible Nanoparticles for in Vivo Imaging Applications

Shu Chen, Lijun Wang, Suzanne L. Duce, Stuart Brown, Stephen Lee, Andreas Melzer, Sir Alfred Cuschieri, Pascal Andre

Research output: Contribution to journal › Article › peer-review

85 Citations (Scopus)

Abstract

Iron-platinum alloy nanoparticles (FePt NPs) are extremely promising candidates for the next generation of contrast agents for magnetic resonance (MR) diagnostic imaging and MR-guided interventions, including hyperthermic ablation of solid cancers. FePt has high Curie temperature, saturation magnetic moment, magneto-crystalline anisotropy, and chemical stability. We describe the synthesis and characterization of a family of biocompatible FePt NPs suitable for biomedical applications, showing and discussing that FePt NPs can exhibit low cytotoxicity. The importance of engineering the interface of strongly magnetic NPs using a coating allowing free aqueous permeation is demonstrated to be an essential parameter in the design of new generations of diagnostic and therapeutic MRI contrast agents. We report effective cell internalization of FePt NPs and demonstrate that they can be used for cellular imaging and in vivo MRI applications. This opens the way for several future applications of FePt NPs, including regenerative medicine and stem cell therapy in addition to enhanced MR diagnostic imaging.

Original language	English
Pages (from-to)	15022-15029
Number of pages	8
Journal	Journal of the American Chemical Society
Volume	132
Issue number	42
DOIs	https://doi.org/10.1021/ja106543j
Publication status	Published - 27 Oct 2010

Keywords

FCT-FEPT NANOPARTICLES
BIOFUNCTIONAL MAGNETIC NANOPARTICLES
MRI CONTRAST AGENTS
SIZE-CONTROLLED FCC
THERMAL-STABILITY
CELLULAR UPTAKE
QUANTUM DOTS
TUNABLE SIZE
HELA-CELLS
MECHANISM

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/ja106543j

Advanced Characterisation of Magnetic: Advanced Characterisation of Magnetic Recording Media using Neutron Scattering
Lee, S. (PI)
EPSRC
1/11/07 → 31/03/11
Project: Standard

Cite this

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title = "Engineered Biocompatible Nanoparticles for in Vivo Imaging Applications",

abstract = "Iron-platinum alloy nanoparticles (FePt NPs) are extremely promising candidates for the next generation of contrast agents for magnetic resonance (MR) diagnostic imaging and MR-guided interventions, including hyperthermic ablation of solid cancers. FePt has high Curie temperature, saturation magnetic moment, magneto-crystalline anisotropy, and chemical stability. We describe the synthesis and characterization of a family of biocompatible FePt NPs suitable for biomedical applications, showing and discussing that FePt NPs can exhibit low cytotoxicity. The importance of engineering the interface of strongly magnetic NPs using a coating allowing free aqueous permeation is demonstrated to be an essential parameter in the design of new generations of diagnostic and therapeutic MRI contrast agents. We report effective cell internalization of FePt NPs and demonstrate that they can be used for cellular imaging and in vivo MRI applications. This opens the way for several future applications of FePt NPs, including regenerative medicine and stem cell therapy in addition to enhanced MR diagnostic imaging.",

keywords = "FCT-FEPT NANOPARTICLES, BIOFUNCTIONAL MAGNETIC NANOPARTICLES, MRI CONTRAST AGENTS, SIZE-CONTROLLED FCC, THERMAL-STABILITY, CELLULAR UPTAKE, QUANTUM DOTS, TUNABLE SIZE, HELA-CELLS, MECHANISM",

author = "Shu Chen and Lijun Wang and Duce, {Suzanne L.} and Stuart Brown and Stephen Lee and Andreas Melzer and Cuschieri, {Sir Alfred} and Pascal Andre",

year = "2010",

month = oct,

day = "27",

doi = "10.1021/ja106543j",

language = "English",

volume = "132",

pages = "15022--15029",

journal = "Journal of the American Chemical Society",

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T1 - Engineered Biocompatible Nanoparticles for in Vivo Imaging Applications

AU - Chen, Shu

AU - Wang, Lijun

AU - Duce, Suzanne L.

AU - Brown, Stuart

AU - Lee, Stephen

AU - Melzer, Andreas

AU - Cuschieri, Sir Alfred

AU - Andre, Pascal

PY - 2010/10/27

Y1 - 2010/10/27

N2 - Iron-platinum alloy nanoparticles (FePt NPs) are extremely promising candidates for the next generation of contrast agents for magnetic resonance (MR) diagnostic imaging and MR-guided interventions, including hyperthermic ablation of solid cancers. FePt has high Curie temperature, saturation magnetic moment, magneto-crystalline anisotropy, and chemical stability. We describe the synthesis and characterization of a family of biocompatible FePt NPs suitable for biomedical applications, showing and discussing that FePt NPs can exhibit low cytotoxicity. The importance of engineering the interface of strongly magnetic NPs using a coating allowing free aqueous permeation is demonstrated to be an essential parameter in the design of new generations of diagnostic and therapeutic MRI contrast agents. We report effective cell internalization of FePt NPs and demonstrate that they can be used for cellular imaging and in vivo MRI applications. This opens the way for several future applications of FePt NPs, including regenerative medicine and stem cell therapy in addition to enhanced MR diagnostic imaging.

AB - Iron-platinum alloy nanoparticles (FePt NPs) are extremely promising candidates for the next generation of contrast agents for magnetic resonance (MR) diagnostic imaging and MR-guided interventions, including hyperthermic ablation of solid cancers. FePt has high Curie temperature, saturation magnetic moment, magneto-crystalline anisotropy, and chemical stability. We describe the synthesis and characterization of a family of biocompatible FePt NPs suitable for biomedical applications, showing and discussing that FePt NPs can exhibit low cytotoxicity. The importance of engineering the interface of strongly magnetic NPs using a coating allowing free aqueous permeation is demonstrated to be an essential parameter in the design of new generations of diagnostic and therapeutic MRI contrast agents. We report effective cell internalization of FePt NPs and demonstrate that they can be used for cellular imaging and in vivo MRI applications. This opens the way for several future applications of FePt NPs, including regenerative medicine and stem cell therapy in addition to enhanced MR diagnostic imaging.

KW - FCT-FEPT NANOPARTICLES

KW - BIOFUNCTIONAL MAGNETIC NANOPARTICLES

KW - MRI CONTRAST AGENTS

KW - SIZE-CONTROLLED FCC

KW - THERMAL-STABILITY

KW - CELLULAR UPTAKE

KW - QUANTUM DOTS

KW - TUNABLE SIZE

KW - HELA-CELLS

KW - MECHANISM

U2 - 10.1021/ja106543j

DO - 10.1021/ja106543j

M3 - Article

SN - 0002-7863

VL - 132

SP - 15022

EP - 15029

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 42

ER -

Engineered Biocompatible Nanoparticles for in Vivo Imaging Applications

Abstract

Keywords

UN SDGs

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Projects

Advanced Characterisation of Magnetic: Advanced Characterisation of Magnetic Recording Media using Neutron Scattering

Cite this