Enantioselective Total Synthesis of (+)-Scuteflorin A Using Organocatalytic Asymmetric Epoxidation

Christopher J. Bartlett, David P. Day, Yohan Chan, Steven M. Allin, Michael J. McKenzie, Alexandra M. Z. Slawin, Philip C. Bulman Page

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

We report the first enantioselective total synthesis of (+)-scuteflorin A in 14% overall yield, employing a chiral iminium salt to effect an organocatalytic asymmetric epoxidation of xanthyletin in >99% ee as the key step.

Original languageEnglish
Pages (from-to)772-774
Number of pages3
JournalThe Journal of Organic Chemistry
Volume77
Issue number1
DOIs
Publication statusPublished - 6 Jan 2012

Keywords

  • IMINIUM SALTS
  • SCUTELLARIA-LATERIFLORA
  • ANGELICA-DECURSIVA
  • CANCER CELLS
  • STEREOSTRUCTURES
  • (+)-DECURSINOL
  • CATALYSTS
  • COUMARIN

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