N-Heterocyclic carbene copper(I) catalysed N-methylation of amines using CO2

Orlando Santoro, Faima Lazreg, Yury Minenkov, Luigi Cavallo, Catherine S.J. Cazin

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83 Citations (Scopus)
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Abstract

The N-methylation of amines using CO2 and PhSiH3 as source of CH3 was efficiently performed using a N-heterocyclic carbene copper(I) complex. The methodology was found compatible with aromatic and aliphatic primary and secondary amines. Synthetic and computational studies have been carried out to support the proposed reaction mechanism for this transformation.

Original languageEnglish
Pages (from-to)18138-18144
JournalDalton Transactions
Volume44
Issue number41
Early online date30 Sept 2015
DOIs
Publication statusPublished - 7 Nov 2015

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