DCDC2, KIAA0319 and CMIP Are Associated with Reading-Related Traits

Tom S. Scerri; Andrew P. Morris; Lyn-Louise Buckingham; Dianne F. Newbury; Laura L. Miller; Anthony P. Monaco; Dorothy V. M. Bishop; Silvia Paracchini

doi:10.1016/j.biopsych.2011.02.005

DCDC2, KIAA0319 and CMIP Are Associated with Reading-Related Traits

Tom S. Scerri, Andrew P. Morris, Lyn-Louise Buckingham, Dianne F. Newbury, Laura L. Miller, Anthony P. Monaco, Dorothy V. M. Bishop, Silvia Paracchini

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Several susceptibility genes have been proposed for dyslexia (reading disability; RD) and specific language impairment (SLI). RD and SLI show comorbidity, but it is unclear whether a common genetic component is shared.

Methods: We have investigated whether candidate genes for RD and SLI affect specific cognitive traits or have broad effect on cognition. We have analyzed common risk variants within RD (MRPL19/C2ORF3, KIAA0319, and DCDC2) and language impairment (CMIP and ATP2C2) candidate loci in the Avon Longitudinal Study of Parents and Children cohort (n = 3725), representing children born in southwest England in the early 1990s.

Results: We detected associations between reading skills and KIAA0319, DCDC2, and CMIP. We show that DCDC2 is specifically associated with RD, whereas variants in CMIP and KIAA0319 are associated with reading skills across the ability range. The strongest associations were restricted to single-word reading and spelling measures, suggesting that these genes do not extend their effect to other reading and language-related skills. Inclusion of individuals with comorbidity tends to strengthen these associations. Our data do not support MRPL19/C2ORF3 as a locus involved in reading abilities nor CMIP/ATP2C2 as genes regulating language skills.

Conclusions: We provide further support for the role of KIAA0319 and DCDC2 in contributing to reading abilities and novel evidence that the language-disorder candidate gene CMIP is also implicated in reading processes. Additionally, we present novel data to evaluate the prevalence and comorbidity of RD and SLI, and we recommend not excluding individuals with comorbid RD and SLI when designing genetic association studies for RD.

Original language	English
Pages (from-to)	237-245
Number of pages	9
Journal	Biological Psychiatry
Volume	70
Issue number	3
Early online date	31 Mar 2011
DOIs	https://doi.org/10.1016/j.biopsych.2011.02.005
Publication status	Published - 1 Aug 2011

Keywords

ALSPAC
association study
dyslexia
language
reading abilities
specific language impairment (SLI)
DEFICIT-HYPERACTIVITY DISORDER
SHORT-TERM-MEMORY
DEVELOPMENTAL DYSLEXIA
LANGUAGE IMPAIRMENT
SUSCEPTIBILITY GENE
CHROMOSOME 6P
AUSTRALIAN POPULATION
NEURONAL MIGRATION
CANDIDATE GENES
CHILDREN

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10.1016/j.biopsych.2011.02.005

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@article{2e785cae4efc41acb013fde543a40b6c,

title = "DCDC2, KIAA0319 and CMIP Are Associated with Reading-Related Traits",

abstract = "Background: Several susceptibility genes have been proposed for dyslexia (reading disability; RD) and specific language impairment (SLI). RD and SLI show comorbidity, but it is unclear whether a common genetic component is shared. Methods: We have investigated whether candidate genes for RD and SLI affect specific cognitive traits or have broad effect on cognition. We have analyzed common risk variants within RD (MRPL19/C2ORF3, KIAA0319, and DCDC2) and language impairment (CMIP and ATP2C2) candidate loci in the Avon Longitudinal Study of Parents and Children cohort (n = 3725), representing children born in southwest England in the early 1990s. Results: We detected associations between reading skills and KIAA0319, DCDC2, and CMIP. We show that DCDC2 is specifically associated with RD, whereas variants in CMIP and KIAA0319 are associated with reading skills across the ability range. The strongest associations were restricted to single-word reading and spelling measures, suggesting that these genes do not extend their effect to other reading and language-related skills. Inclusion of individuals with comorbidity tends to strengthen these associations. Our data do not support MRPL19/C2ORF3 as a locus involved in reading abilities nor CMIP/ATP2C2 as genes regulating language skills. Conclusions: We provide further support for the role of KIAA0319 and DCDC2 in contributing to reading abilities and novel evidence that the language-disorder candidate gene CMIP is also implicated in reading processes. Additionally, we present novel data to evaluate the prevalence and comorbidity of RD and SLI, and we recommend not excluding individuals with comorbid RD and SLI when designing genetic association studies for RD.",

keywords = "ALSPAC, association study, dyslexia, language, reading abilities, specific language impairment (SLI), DEFICIT-HYPERACTIVITY DISORDER, SHORT-TERM-MEMORY, DEVELOPMENTAL DYSLEXIA, LANGUAGE IMPAIRMENT, SUSCEPTIBILITY GENE, CHROMOSOME 6P, AUSTRALIAN POPULATION, NEURONAL MIGRATION, CANDIDATE GENES, CHILDREN",

author = "Scerri, {Tom S.} and Morris, {Andrew P.} and Lyn-Louise Buckingham and Newbury, {Dianne F.} and Miller, {Laura L.} and Monaco, {Anthony P.} and Bishop, {Dorothy V. M.} and Silvia Paracchini",

year = "2011",

month = aug,

day = "1",

doi = "10.1016/j.biopsych.2011.02.005",

language = "English",

volume = "70",

pages = "237--245",

journal = "Biological Psychiatry",

issn = "0006-3223",

publisher = "Elsevier Inc.",

number = "3",

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T1 - DCDC2, KIAA0319 and CMIP Are Associated with Reading-Related Traits

AU - Scerri, Tom S.

AU - Morris, Andrew P.

AU - Buckingham, Lyn-Louise

AU - Newbury, Dianne F.

AU - Miller, Laura L.

AU - Monaco, Anthony P.

AU - Bishop, Dorothy V. M.

AU - Paracchini, Silvia

PY - 2011/8/1

Y1 - 2011/8/1

N2 - Background: Several susceptibility genes have been proposed for dyslexia (reading disability; RD) and specific language impairment (SLI). RD and SLI show comorbidity, but it is unclear whether a common genetic component is shared. Methods: We have investigated whether candidate genes for RD and SLI affect specific cognitive traits or have broad effect on cognition. We have analyzed common risk variants within RD (MRPL19/C2ORF3, KIAA0319, and DCDC2) and language impairment (CMIP and ATP2C2) candidate loci in the Avon Longitudinal Study of Parents and Children cohort (n = 3725), representing children born in southwest England in the early 1990s. Results: We detected associations between reading skills and KIAA0319, DCDC2, and CMIP. We show that DCDC2 is specifically associated with RD, whereas variants in CMIP and KIAA0319 are associated with reading skills across the ability range. The strongest associations were restricted to single-word reading and spelling measures, suggesting that these genes do not extend their effect to other reading and language-related skills. Inclusion of individuals with comorbidity tends to strengthen these associations. Our data do not support MRPL19/C2ORF3 as a locus involved in reading abilities nor CMIP/ATP2C2 as genes regulating language skills. Conclusions: We provide further support for the role of KIAA0319 and DCDC2 in contributing to reading abilities and novel evidence that the language-disorder candidate gene CMIP is also implicated in reading processes. Additionally, we present novel data to evaluate the prevalence and comorbidity of RD and SLI, and we recommend not excluding individuals with comorbid RD and SLI when designing genetic association studies for RD.

AB - Background: Several susceptibility genes have been proposed for dyslexia (reading disability; RD) and specific language impairment (SLI). RD and SLI show comorbidity, but it is unclear whether a common genetic component is shared. Methods: We have investigated whether candidate genes for RD and SLI affect specific cognitive traits or have broad effect on cognition. We have analyzed common risk variants within RD (MRPL19/C2ORF3, KIAA0319, and DCDC2) and language impairment (CMIP and ATP2C2) candidate loci in the Avon Longitudinal Study of Parents and Children cohort (n = 3725), representing children born in southwest England in the early 1990s. Results: We detected associations between reading skills and KIAA0319, DCDC2, and CMIP. We show that DCDC2 is specifically associated with RD, whereas variants in CMIP and KIAA0319 are associated with reading skills across the ability range. The strongest associations were restricted to single-word reading and spelling measures, suggesting that these genes do not extend their effect to other reading and language-related skills. Inclusion of individuals with comorbidity tends to strengthen these associations. Our data do not support MRPL19/C2ORF3 as a locus involved in reading abilities nor CMIP/ATP2C2 as genes regulating language skills. Conclusions: We provide further support for the role of KIAA0319 and DCDC2 in contributing to reading abilities and novel evidence that the language-disorder candidate gene CMIP is also implicated in reading processes. Additionally, we present novel data to evaluate the prevalence and comorbidity of RD and SLI, and we recommend not excluding individuals with comorbid RD and SLI when designing genetic association studies for RD.

KW - ALSPAC

KW - association study

KW - dyslexia

KW - language

KW - reading abilities

KW - specific language impairment (SLI)

KW - DEFICIT-HYPERACTIVITY DISORDER

KW - SHORT-TERM-MEMORY

KW - DEVELOPMENTAL DYSLEXIA

KW - LANGUAGE IMPAIRMENT

KW - SUSCEPTIBILITY GENE

KW - CHROMOSOME 6P

KW - AUSTRALIAN POPULATION

KW - NEURONAL MIGRATION

KW - CANDIDATE GENES

KW - CHILDREN

U2 - 10.1016/j.biopsych.2011.02.005

DO - 10.1016/j.biopsych.2011.02.005

M3 - Article

SN - 0006-3223

VL - 70

SP - 237

EP - 245

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 3

ER -

DCDC2, KIAA0319 and CMIP Are Associated with Reading-Related Traits

Abstract

Keywords

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