Electrical conductivity measurement in Thiel-embalmed tissue model: relevance to radiofrequency ablation

Z. Wang; H. Luo; M. Nick; M. Gueorguieva; P. Andre; R.T. Baker; D. McLean; S. Brown; A. Cuschieri

doi:10.1049/el.2014.1934

Electrical conductivity measurement in Thiel-embalmed tissue model: relevance to radiofrequency ablation

Z. Wang
, H. Luo
, M. Nick
, M. Gueorguieva
, P. Andre
, R.T. Baker
, D. McLean
, S. Brown
, A. Cuschieri

Research output: Contribution to journal › Article › peer-review

Abstract

Thiel-embalmed human cadaveric specimens are used widely for biomedical scientific investigation. This Letter reports electrical impedance measurements of Thiel-embalming solutions from 1 Hz to 32 MHz. Compared with other solutions studied, Thiel solution has the lowest impedance throughout the test spectrum. The electrical conductivity of a Thiel-embalmed liver sample exhibited a relatively flat frequency response from 100 to 500 kHz, which is the frequency range used for electro-surgery and radiofrequency tumour ablation (RFA). It measured 5 Sm^-1 compared with 0.22 Sm^-1 obtained from ex-vivo fresh pig liver. Using finite element modelling and experimental evaluation, the ablation zone obtained from the Thiel-embalmed liver sample was extremely small due to its much higher conductivity. Hence, it is concluded that Thiel-embalmed tissue cannot be used as a reliable model for RFA evaluation.

Original language	English
Pages (from-to)	1125-1127
Number of pages	3
Journal	Electronics Letters
Volume	50
Issue number	16
Early online date	22 Jul 2014
DOIs	https://doi.org/10.1049/el.2014.1934
Publication status	Published - 31 Jul 2014

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baker2014electroniclett1125
© 2014. The Institution of Engineering and Technology. This paper is a postprint of a paper submitted to and accepted for publication in Electronics Letters and is subject to Institution of Engineering and Technology Copyright. The copy of record is available at IET Digital Library
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title = "Electrical conductivity measurement in Thiel-embalmed tissue model: relevance to radiofrequency ablation",

abstract = "Thiel-embalmed human cadaveric specimens are used widely for biomedical scientific investigation. This Letter reports electrical impedance measurements of Thiel-embalming solutions from 1 Hz to 32 MHz. Compared with other solutions studied, Thiel solution has the lowest impedance throughout the test spectrum. The electrical conductivity of a Thiel-embalmed liver sample exhibited a relatively flat frequency response from 100 to 500 kHz, which is the frequency range used for electro-surgery and radiofrequency tumour ablation (RFA). It measured 5 Sm-1 compared with 0.22 Sm-1 obtained from ex-vivo fresh pig liver. Using finite element modelling and experimental evaluation, the ablation zone obtained from the Thiel-embalmed liver sample was extremely small due to its much higher conductivity. Hence, it is concluded that Thiel-embalmed tissue cannot be used as a reliable model for RFA evaluation.",

author = "Z. Wang and H. Luo and M. Nick and M. Gueorguieva and P. Andre and R.T. Baker and D. McLean and S. Brown and A. Cuschieri",

note = "PA gratefully acknowledges SUPA for funding his Advanced Research Fellowship.",

year = "2014",

month = jul,

day = "31",

doi = "10.1049/el.2014.1934",

language = "English",

volume = "50",

pages = "1125--1127",

journal = "Electronics Letters",

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TY - JOUR

T1 - Electrical conductivity measurement in Thiel-embalmed tissue model

T2 - relevance to radiofrequency ablation

AU - Wang, Z.

AU - Luo, H.

AU - Nick, M.

AU - Gueorguieva, M.

AU - Andre, P.

AU - Baker, R.T.

AU - McLean, D.

AU - Brown, S.

AU - Cuschieri, A.

N1 - PA gratefully acknowledges SUPA for funding his Advanced Research Fellowship.

PY - 2014/7/31

Y1 - 2014/7/31

N2 - Thiel-embalmed human cadaveric specimens are used widely for biomedical scientific investigation. This Letter reports electrical impedance measurements of Thiel-embalming solutions from 1 Hz to 32 MHz. Compared with other solutions studied, Thiel solution has the lowest impedance throughout the test spectrum. The electrical conductivity of a Thiel-embalmed liver sample exhibited a relatively flat frequency response from 100 to 500 kHz, which is the frequency range used for electro-surgery and radiofrequency tumour ablation (RFA). It measured 5 Sm-1 compared with 0.22 Sm-1 obtained from ex-vivo fresh pig liver. Using finite element modelling and experimental evaluation, the ablation zone obtained from the Thiel-embalmed liver sample was extremely small due to its much higher conductivity. Hence, it is concluded that Thiel-embalmed tissue cannot be used as a reliable model for RFA evaluation.

AB - Thiel-embalmed human cadaveric specimens are used widely for biomedical scientific investigation. This Letter reports electrical impedance measurements of Thiel-embalming solutions from 1 Hz to 32 MHz. Compared with other solutions studied, Thiel solution has the lowest impedance throughout the test spectrum. The electrical conductivity of a Thiel-embalmed liver sample exhibited a relatively flat frequency response from 100 to 500 kHz, which is the frequency range used for electro-surgery and radiofrequency tumour ablation (RFA). It measured 5 Sm-1 compared with 0.22 Sm-1 obtained from ex-vivo fresh pig liver. Using finite element modelling and experimental evaluation, the ablation zone obtained from the Thiel-embalmed liver sample was extremely small due to its much higher conductivity. Hence, it is concluded that Thiel-embalmed tissue cannot be used as a reliable model for RFA evaluation.

U2 - 10.1049/el.2014.1934

DO - 10.1049/el.2014.1934

M3 - Article

AN - SCOPUS:84905254834

SN - 0013-5194

VL - 50

SP - 1125

EP - 1127

JO - Electronics Letters

JF - Electronics Letters

IS - 16

ER -

Electrical conductivity measurement in Thiel-embalmed tissue model: relevance to radiofrequency ablation

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