Efficient synthesis of novel chalcogen-containing derivatives of DNA nucleobases

Guoxiong Hua, Junyi Du, David Bradford Cordes, Alexandra Martha Zoya Slawin, J Derek Woollins

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Abstract

The formation of a library of chalcogen-containing DNA nucleobase derivatives is presented. Reacting easily accessible 9-(2-bromoethyl)adenine with chalcogen-containing nucleophilic reagents led to a series of novel heteroatom derivatives incorporating S, Se and Te atoms prepared in satisfactory yields. Two representative X-ray structures are reported
Original languageEnglish
Pages (from-to)1792-1798
JournalTetrahedron
Volume71
Issue number12
Early online date7 Feb 2015
DOIs
Publication statusPublished - 25 Mar 2015

Keywords

  • DNA nucleobases
  • 9-(2-Bromoethyl)adenine
  • Adenine derivatives
  • Chalcogens
  • Woollins’ reagent

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