Abstract
An N-heterocyclic carbene promotes the rearrangement of alpha-amino acid derived O-acyl carbonates to their corresponding C-acylated isomers, generating a C-C bond and a quaternary stereocenter with high efficiency, under mild reaction conditions and with low catalyst loadings.
Original language | English |
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Pages (from-to) | 3785-3788 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 8 |
Issue number | 17 |
DOIs | |
Publication status | Published - 17 Aug 2006 |
Keywords
- INTRAMOLECULAR STETTER REACTION
- NUCLEOPHILIC CARBENES
- TRANSESTERIFICATION/ACYLATION REACTIONS
- ALPHA,BETA-UNSATURATED ALDEHYDES
- LIVING POLYMERIZATION
- GAMMA-BUTYROLACTONES
- QUATERNARY CARBON
- 1ST EXAMPLE
- ACYLATION
- ESTERS