Efficient biotransformations in Cunninghamella elegans and Streptomyces sp. JCM9888 of selectively fluorinated benzoic acids to the corresponding benzamides and benzyl alcohols

Oluwayinka O. Oke; Yawen Chen; Chukwuemeka Isanbor; Olayinka T. Asekun; David O'Hagan

doi:10.1080/10242422.2023.2267156

Efficient biotransformations in Cunninghamella elegans and Streptomyces sp. JCM9888 of selectively fluorinated benzoic acids to the corresponding benzamides and benzyl alcohols

Oluwayinka O. Oke, Yawen Chen, Chukwuemeka Isanbor, Olayinka T. Asekun, David O'Hagan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

An efficient conversion of ortho, meta and para fluoro- and trifluoromethyl-substituted benzoic acids to the corresponding benzamides in fermentations of the soil bacterium Streptomyces sp. JCM9888 is described. We also report the efficient reduction of the same class of substrates to the corresponding benzyl alcohols with the fungi Cunninghamella elegans. These biotransformations were surprisingly efficient and may have value as disruptive technologies in process chemistry.

Original language	English
Journal	Biocatalysis and Biotransformation
Volume	Latest Articles
Early online date	12 Oct 2023
DOIs	https://doi.org/10.1080/10242422.2023.2267156
Publication status	E-pub ahead of print - 12 Oct 2023

Keywords

Biotransformations
Streptomyces sp. JCM9888
Cunninghamella elegans DSM1908
Benzoic acids
Benzamides
Benzyl alcohols

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10.1080/10242422.2023.2267156Licence: CC BY-NC-ND

Oke_2023_BB_Efficientbiotransformations_CCBYNCND
Copyright © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
Final published version, 906 KBLicence: CC BY-NC-ND

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Oke, O. O., Chen, Y., Isanbor, C., Asekun, O. T., & O'Hagan, D. (2023). Efficient biotransformations in Cunninghamella elegans and Streptomyces sp. JCM9888 of selectively fluorinated benzoic acids to the corresponding benzamides and benzyl alcohols. Biocatalysis and Biotransformation, Latest Articles. Advance online publication. https://doi.org/10.1080/10242422.2023.2267156

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title = "Efficient biotransformations in Cunninghamella elegans and Streptomyces sp. JCM9888 of selectively fluorinated benzoic acids to the corresponding benzamides and benzyl alcohols",

abstract = "An efficient conversion of ortho, meta and para fluoro- and trifluoromethyl-substituted benzoic acids to the corresponding benzamides in fermentations of the soil bacterium Streptomyces sp. JCM9888 is described. We also report the efficient reduction of the same class of substrates to the corresponding benzyl alcohols with the fungi Cunninghamella elegans. These biotransformations were surprisingly efficient and may have value as disruptive technologies in process chemistry.",

keywords = "Biotransformations, Streptomyces sp. JCM9888, Cunninghamella elegans DSM1908, Benzoic acids, Benzamides, Benzyl alcohols",

author = "Oke, {Oluwayinka O.} and Yawen Chen and Chukwuemeka Isanbor and Asekun, {Olayinka T.} and David O'Hagan",

note = "Support was received from the Commonwealth Scholarship Council for a Split Site Studentship (OO) and also from the Royal Society of Chemistry for a travel Grant (C.I).",

year = "2023",

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day = "12",

doi = "10.1080/10242422.2023.2267156",

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Efficient biotransformations in Cunninghamella elegans and Streptomyces sp. JCM9888 of selectively fluorinated benzoic acids to the corresponding benzamides and benzyl alcohols. / Oke, Oluwayinka O.; Chen, Yawen; Isanbor, Chukwuemeka et al.
In: Biocatalysis and Biotransformation, Vol. Latest Articles, 12.10.2023.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Efficient biotransformations in Cunninghamella elegans and Streptomyces sp. JCM9888 of selectively fluorinated benzoic acids to the corresponding benzamides and benzyl alcohols

AU - Oke, Oluwayinka O.

AU - Chen, Yawen

AU - Isanbor, Chukwuemeka

AU - Asekun, Olayinka T.

AU - O'Hagan, David

N1 - Support was received from the Commonwealth Scholarship Council for a Split Site Studentship (OO) and also from the Royal Society of Chemistry for a travel Grant (C.I).

PY - 2023/10/12

Y1 - 2023/10/12

N2 - An efficient conversion of ortho, meta and para fluoro- and trifluoromethyl-substituted benzoic acids to the corresponding benzamides in fermentations of the soil bacterium Streptomyces sp. JCM9888 is described. We also report the efficient reduction of the same class of substrates to the corresponding benzyl alcohols with the fungi Cunninghamella elegans. These biotransformations were surprisingly efficient and may have value as disruptive technologies in process chemistry.

AB - An efficient conversion of ortho, meta and para fluoro- and trifluoromethyl-substituted benzoic acids to the corresponding benzamides in fermentations of the soil bacterium Streptomyces sp. JCM9888 is described. We also report the efficient reduction of the same class of substrates to the corresponding benzyl alcohols with the fungi Cunninghamella elegans. These biotransformations were surprisingly efficient and may have value as disruptive technologies in process chemistry.

KW - Biotransformations

KW - Streptomyces sp. JCM9888

KW - Cunninghamella elegans DSM1908

KW - Benzoic acids

KW - Benzamides

KW - Benzyl alcohols

U2 - 10.1080/10242422.2023.2267156

DO - 10.1080/10242422.2023.2267156

M3 - Article

SN - 1024-2422

VL - Latest Articles

JO - Biocatalysis and Biotransformation

JF - Biocatalysis and Biotransformation

ER -

Efficient biotransformations in Cunninghamella elegans and Streptomyces sp. JCM9888 of selectively fluorinated benzoic acids to the corresponding benzamides and benzyl alcohols

Abstract

Keywords

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