Efficient biotransformations in Cunninghamella elegans and Streptomyces sp. JCM9888 of selectively fluorinated benzoic acids to the corresponding benzamides and benzyl alcohols

Oluwayinka O. Oke, Yawen Chen, Chukwuemeka Isanbor, Olayinka T. Asekun, David O'Hagan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

An efficient conversion of ortho, meta and para fluoro- and trifluoromethyl-substituted benzoic acids to the corresponding benzamides in fermentations of the soil bacterium Streptomyces sp. JCM9888 is described. We also report the efficient reduction of the same class of substrates to the corresponding benzyl alcohols with the fungi Cunninghamella elegans. These biotransformations were surprisingly efficient and may have value as disruptive technologies in process chemistry.
Original languageEnglish
JournalBiocatalysis and Biotransformation
VolumeLatest Articles
Early online date12 Oct 2023
DOIs
Publication statusE-pub ahead of print - 12 Oct 2023

Keywords

  • Biotransformations
  • Streptomyces sp. JCM9888
  • Cunninghamella elegans DSM1908
  • Benzoic acids
  • Benzamides
  • Benzyl alcohols

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