Efficient access to 2,5-substituted tetrahydrofurans via a one-pot cyclization of di- and triepoxides

Gordon J. Florence, Rornain Cadou

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The one-pot addition and cyclization of 1,5-diepoxyhexane with a range of organolithium species provides efficient access to 2,5-substituted tetrahydrofurans (THFs), common structural motifs found in a range of natural products and pharmaceutical ingredients, Extension of this reaction to triepoxides has also been demonstrated to access adjacently linked bis-THF motifs in a single step. (C) 2008 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)6784-6786
Number of pages3
JournalTetrahedron Letters
Volume49
Issue number48
DOIs
Publication statusPublished - 24 Nov 2008

Keywords

  • KINETIC RESOLUTION
  • TERMINAL EPOXIDES

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