Abstract
This study investigated the impact of sleep deprivation on the human circadian system. Plasma melatonin and cortisol levels and leukocyte expression levels of 12 genes were examined over 48 h (sleep vs. no-sleep nights) in 12 young males (mean±SD: 23±5 yrs). During one night of total sleep deprivation, BMAL1 expression was suppressed, the heat shock gene HSPA1B expression was induced, and the amplitude of the melatonin rhythm increased, whereas other high-amplitude clock gene rhythms (e.g., PER1-3, REV-ERBα) remained unaffected. These data suggest that the core clock mechanism in peripheral oscillators is compromised during acute sleep deprivation.
Original language | English |
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Pages (from-to) | 901-9 |
Number of pages | 9 |
Journal | Chronobiology International |
Volume | 30 |
Issue number | 7 |
DOIs | |
Publication status | Published - Aug 2013 |
Keywords
- ARNTL Transcription Factors
- Adult
- Circadian Rhythm
- Gene Expression Profiling
- Gene Expression Regulation
- HSP70 Heat-Shock Proteins
- Humans
- Hydrocortisone
- Leukocytes
- Light
- Male
- Melatonin
- Nuclear Receptor Subfamily 1, Group D, Member 1
- Oscillometry
- Oxidative Stress
- Period Circadian Proteins
- Radioimmunoassay
- Sleep
- Sleep Deprivation
- Time Factors
- Young Adult
- Journal Article
- Research Support, Non-U.S. Gov't