Effect of sleep deprivation on rhythms of clock gene expression and melatonin in humans

Katrin Ackermann, Rosina Plomp, Oscar Lao, Benita Middleton, Victoria L Revell, Debra J Skene, Manfred Kayser

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)


This study investigated the impact of sleep deprivation on the human circadian system. Plasma melatonin and cortisol levels and leukocyte expression levels of 12 genes were examined over 48 h (sleep vs. no-sleep nights) in 12 young males (mean±SD: 23±5 yrs). During one night of total sleep deprivation, BMAL1 expression was suppressed, the heat shock gene HSPA1B expression was induced, and the amplitude of the melatonin rhythm increased, whereas other high-amplitude clock gene rhythms (e.g., PER1-3, REV-ERBα) remained unaffected. These data suggest that the core clock mechanism in peripheral oscillators is compromised during acute sleep deprivation.

Original languageEnglish
Pages (from-to)901-9
Number of pages9
JournalChronobiology International
Issue number7
Publication statusPublished - Aug 2013


  • ARNTL Transcription Factors
  • Adult
  • Circadian Rhythm
  • Gene Expression Profiling
  • Gene Expression Regulation
  • HSP70 Heat-Shock Proteins
  • Humans
  • Hydrocortisone
  • Leukocytes
  • Light
  • Male
  • Melatonin
  • Nuclear Receptor Subfamily 1, Group D, Member 1
  • Oscillometry
  • Oxidative Stress
  • Period Circadian Proteins
  • Radioimmunoassay
  • Sleep
  • Sleep Deprivation
  • Time Factors
  • Young Adult
  • Journal Article
  • Research Support, Non-U.S. Gov't


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