Effect of Redundant Chain Packing on the Uptake of Calcium Phosphate in Poly(2-hydroxyethyl methacrylate) Hydrogels

TV Chirila; AJ Hill; David Trevor Richens

doi:10.1071/CH07111

Effect of Redundant Chain Packing on the Uptake of Calcium Phosphate in Poly(2-hydroxyethyl methacrylate) Hydrogels

TV Chirila, AJ Hill, David Trevor Richens

School of Chemistry

Research output: Contribution to journal › Article › peer-review

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Abstract

A method is described that allows reduction of the amount of calcium phosphate phases deposited spontaneously inside poly(2-hydroxyethyl methacrylate) (PHEMA), a hydrogel of biomedical importance. PHEMA homo-interpenetrating polymer networks (homo-IPNs) were synthesized and then treated in a calcifying solution. A reduction of calcium uptake of 58 to 75% was measured by ICP emission spectroscopy in the IPNs as compared to the PHEMA homopolymer ( the parent network). The effect was rationalized in terms of reduction of the free volume available for the penetration and transport of Ca2+ and phosphate ions as a result of redundant chain packing through formation of IPNs.

Original language	English
Pages (from-to)	439-443
Number of pages	5
Journal	Australian Journal of Chemistry
Volume	60
DOIs	https://doi.org/10.1071/CH07111
Publication status	Published - 2007

Keywords

MOLECULAR-DYNAMICS SIMULATION
INTERNAL FREE-VOLUME
ACRYLIC HYDROGELS
SOLUTE DIFFUSION
INTRAOCULAR-LENS
HYDRATION
IONS
TRANSPORT
POLYMER
CALCIFICATION

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10.1071/CH07111

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title = "Effect of Redundant Chain Packing on the Uptake of Calcium Phosphate in Poly(2-hydroxyethyl methacrylate) Hydrogels",

abstract = "A method is described that allows reduction of the amount of calcium phosphate phases deposited spontaneously inside poly(2-hydroxyethyl methacrylate) (PHEMA), a hydrogel of biomedical importance. PHEMA homo-interpenetrating polymer networks (homo-IPNs) were synthesized and then treated in a calcifying solution. A reduction of calcium uptake of 58 to 75% was measured by ICP emission spectroscopy in the IPNs as compared to the PHEMA homopolymer ( the parent network). The effect was rationalized in terms of reduction of the free volume available for the penetration and transport of Ca2+ and phosphate ions as a result of redundant chain packing through formation of IPNs.",

keywords = "MOLECULAR-DYNAMICS SIMULATION, INTERNAL FREE-VOLUME, ACRYLIC HYDROGELS, SOLUTE DIFFUSION, INTRAOCULAR-LENS, HYDRATION, IONS, TRANSPORT, POLYMER, CALCIFICATION",

author = "TV Chirila and AJ Hill and Richens, {David Trevor}",

year = "2007",

doi = "10.1071/CH07111",

language = "English",

volume = "60",

pages = "439--443",

journal = "Australian Journal of Chemistry",

issn = "0004-9425",

publisher = "CSIRO",

}

TY - JOUR

T1 - Effect of Redundant Chain Packing on the Uptake of Calcium Phosphate in Poly(2-hydroxyethyl methacrylate) Hydrogels

AU - Chirila, TV

AU - Hill, AJ

AU - Richens, David Trevor

PY - 2007

Y1 - 2007

N2 - A method is described that allows reduction of the amount of calcium phosphate phases deposited spontaneously inside poly(2-hydroxyethyl methacrylate) (PHEMA), a hydrogel of biomedical importance. PHEMA homo-interpenetrating polymer networks (homo-IPNs) were synthesized and then treated in a calcifying solution. A reduction of calcium uptake of 58 to 75% was measured by ICP emission spectroscopy in the IPNs as compared to the PHEMA homopolymer ( the parent network). The effect was rationalized in terms of reduction of the free volume available for the penetration and transport of Ca2+ and phosphate ions as a result of redundant chain packing through formation of IPNs.

AB - A method is described that allows reduction of the amount of calcium phosphate phases deposited spontaneously inside poly(2-hydroxyethyl methacrylate) (PHEMA), a hydrogel of biomedical importance. PHEMA homo-interpenetrating polymer networks (homo-IPNs) were synthesized and then treated in a calcifying solution. A reduction of calcium uptake of 58 to 75% was measured by ICP emission spectroscopy in the IPNs as compared to the PHEMA homopolymer ( the parent network). The effect was rationalized in terms of reduction of the free volume available for the penetration and transport of Ca2+ and phosphate ions as a result of redundant chain packing through formation of IPNs.

KW - MOLECULAR-DYNAMICS SIMULATION

KW - INTERNAL FREE-VOLUME

KW - ACRYLIC HYDROGELS

KW - SOLUTE DIFFUSION

KW - INTRAOCULAR-LENS

KW - HYDRATION

KW - IONS

KW - TRANSPORT

KW - POLYMER

KW - CALCIFICATION

UR - http://www.scopus.com/inward/record.url?scp=34250900456&partnerID=8YFLogxK

UR - http://www.publish.csiro.au/paper/CH07111.htm

U2 - 10.1071/CH07111

DO - 10.1071/CH07111

M3 - Article

SN - 0004-9425

VL - 60

SP - 439

EP - 443

JO - Australian Journal of Chemistry

JF - Australian Journal of Chemistry

ER -

Effect of Redundant Chain Packing on the Uptake of Calcium Phosphate in Poly(2-hydroxyethyl methacrylate) Hydrogels

Abstract

Keywords

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