Effect of Electronic Enrichment of NHCs on the Catalytic Activity of [Pd(NHC)(acac)Cl] in Buchwald−Hartwig Coupling

Gaetan Romain Le Duc; Sebastien Michel Bernard Meiries; Steven Patrick Nolan

doi:10.1021/om4010143

Effect of Electronic Enrichment of NHCs on the Catalytic Activity of [Pd(NHC)(acac)Cl] in Buchwald−Hartwig Coupling

Gaetan Romain Le Duc, Sebastien Michel Bernard Meiries, Steven Patrick Nolan

Research output: Contribution to journal › Article › peer-review

Abstract

A series of [Pd(NHC)(acac)Cl] (NHC = Nheterocyclic carbene) complexes have been synthesized and characterized to investigate the electronic and steric effects of NHC ligands in catalysis. Their reactivity in Buchwald−Hartwig coupling has been explored and compared with that of their nonmethoxylated congeners. Combining the optimal steric and electronic properties, [Pd(IHeptOMe)(acac)Cl] performed excellently in the palladium-catalyzed amination of deactivated aryl chlorides with various anilines.

Original language	English
Pages (from-to)	7547-7551
Number of pages	5
Journal	Organometallics
Volume	32
Issue number	24
Early online date	19 Nov 2013
DOIs	https://doi.org/10.1021/om4010143
Publication status	Published - 23 Dec 2013

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title = "Effect of Electronic Enrichment of NHCs on the Catalytic Activity of [Pd(NHC)(acac)Cl] in Buchwald−Hartwig Coupling",

abstract = "A series of [Pd(NHC)(acac)Cl] (NHC = Nheterocyclic carbene) complexes have been synthesized and characterized to investigate the electronic and steric effects of NHC ligands in catalysis. Their reactivity in Buchwald−Hartwig coupling has been explored and compared with that of their nonmethoxylated congeners. Combining the optimal steric and electronic properties, [Pd(IHeptOMe)(acac)Cl] performed excellently in the palladium-catalyzed amination of deactivated aryl chlorides with various anilines.",

author = "{Le Duc}, {Gaetan Romain} and Meiries, {Sebastien Michel Bernard} and Nolan, {Steven Patrick}",

year = "2013",

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doi = "10.1021/om4010143",

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journal = "Organometallics",

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publisher = "American Chemical Society (ACS)",

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T1 - Effect of Electronic Enrichment of NHCs on the Catalytic Activity of [Pd(NHC)(acac)Cl] in Buchwald−Hartwig Coupling

AU - Le Duc, Gaetan Romain

AU - Meiries, Sebastien Michel Bernard

AU - Nolan, Steven Patrick

PY - 2013/12/23

Y1 - 2013/12/23

N2 - A series of [Pd(NHC)(acac)Cl] (NHC = Nheterocyclic carbene) complexes have been synthesized and characterized to investigate the electronic and steric effects of NHC ligands in catalysis. Their reactivity in Buchwald−Hartwig coupling has been explored and compared with that of their nonmethoxylated congeners. Combining the optimal steric and electronic properties, [Pd(IHeptOMe)(acac)Cl] performed excellently in the palladium-catalyzed amination of deactivated aryl chlorides with various anilines.

AB - A series of [Pd(NHC)(acac)Cl] (NHC = Nheterocyclic carbene) complexes have been synthesized and characterized to investigate the electronic and steric effects of NHC ligands in catalysis. Their reactivity in Buchwald−Hartwig coupling has been explored and compared with that of their nonmethoxylated congeners. Combining the optimal steric and electronic properties, [Pd(IHeptOMe)(acac)Cl] performed excellently in the palladium-catalyzed amination of deactivated aryl chlorides with various anilines.

U2 - 10.1021/om4010143

DO - 10.1021/om4010143

M3 - Article

SN - 0276-7333

VL - 32

SP - 7547

EP - 7551

JO - Organometallics

JF - Organometallics

IS - 24

ER -

Effect of Electronic Enrichment of NHCs on the Catalytic Activity of [Pd(NHC)(acac)Cl] in Buchwald−Hartwig Coupling

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