Effect of carboxylic acid xenobiotics and their metabolites on the activity of carnitine acyltransferases

D. A. Vessey; W. Chen; R. R. Ramsay

doi:10.1042/bj2790895

Effect of carboxylic acid xenobiotics and their metabolites on the activity of carnitine acyltransferases

D. A. Vessey^*, W. Chen, R. R. Ramsay

^*Corresponding author for this work

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10 Citations (Scopus)

Abstract

Salicylyl-CoA and benzoyl-CoA were good inhibitors of carnitine acetyltransferase (CAT), competing with acetyl-CoA with K(i) values of 7.5 and 22 μM respectively in the forward direction and with CoA in the reverse reaction with similar K(i) values. They were also competitive inhibitors of carnitine octanoyltransferase (K(i) = 261 and 295 μM respectively), but were only weakly inhibitory to carnitine palmitoyltransferase. Inhibition of energy production by salicylate may result from the inhibition of CAT by salicylyl-CoA.

Original language	English
Pages (from-to)	895-897
Number of pages	3
Journal	Biochemical Journal
Volume	279
Issue number	3
DOIs	https://doi.org/10.1042/bj2790895
Publication status	Published - 1 Jan 1991

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abstract = "Salicylyl-CoA and benzoyl-CoA were good inhibitors of carnitine acetyltransferase (CAT), competing with acetyl-CoA with K(i) values of 7.5 and 22 μM respectively in the forward direction and with CoA in the reverse reaction with similar K(i) values. They were also competitive inhibitors of carnitine octanoyltransferase (K(i) = 261 and 295 μM respectively), but were only weakly inhibitory to carnitine palmitoyltransferase. Inhibition of energy production by salicylate may result from the inhibition of CAT by salicylyl-CoA.",

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AU - Ramsay, R. R.

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AB - Salicylyl-CoA and benzoyl-CoA were good inhibitors of carnitine acetyltransferase (CAT), competing with acetyl-CoA with K(i) values of 7.5 and 22 μM respectively in the forward direction and with CoA in the reverse reaction with similar K(i) values. They were also competitive inhibitors of carnitine octanoyltransferase (K(i) = 261 and 295 μM respectively), but were only weakly inhibitory to carnitine palmitoyltransferase. Inhibition of energy production by salicylate may result from the inhibition of CAT by salicylyl-CoA.

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Effect of carboxylic acid xenobiotics and their metabolites on the activity of carnitine acyltransferases

Abstract

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