Echoviruses bind heparan sulfate at the cell surface

IG Goodfellow; AB Sioofy; RM Powell; DJ Evans

Echoviruses bind heparan sulfate at the cell surface

IG Goodfellow, AB Sioofy, RM Powell, DJ Evans^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Some echoviruses (EV) that bind decay-accelerating factor (DAF) also bind cells of human and murine origins in a DAF-independent manner. Pretreatment of cells with heparinase 1 or heparin blocks the binding of radiolabeled virus to the cell surface, and heparin prevents infection of rhabdomyosarcoma cells by certain EV, including several low-passage clinical isolates of EV 6 and some EV that do not bind DAF. These studies suggest that heparan sulfate may be of in vivo relevance as an attachment molecule for EV.

Original language	English
Pages (from-to)	4918-4921
Number of pages	4
Journal	Journal of Virology
Volume	75
Issue number	10
Publication status	Published - May 2001

Keywords

DECAY-ACCELERATING FACTOR
MOUTH-DISEASE-VIRUS
RESPIRATORY SYNCYTIAL VIRUS
COMPLEMENT REGULATORY PROTEIN
FACTOR CD55
FACTOR DAF
RECEPTOR
ATTACHMENT
INFECTIVITY
REQUIRES

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@article{984b19a7c71f4274a767d80040413f24,

title = "Echoviruses bind heparan sulfate at the cell surface",

abstract = "Some echoviruses (EV) that bind decay-accelerating factor (DAF) also bind cells of human and murine origins in a DAF-independent manner. Pretreatment of cells with heparinase 1 or heparin blocks the binding of radiolabeled virus to the cell surface, and heparin prevents infection of rhabdomyosarcoma cells by certain EV, including several low-passage clinical isolates of EV 6 and some EV that do not bind DAF. These studies suggest that heparan sulfate may be of in vivo relevance as an attachment molecule for EV.",

keywords = "DECAY-ACCELERATING FACTOR, MOUTH-DISEASE-VIRUS, RESPIRATORY SYNCYTIAL VIRUS, COMPLEMENT REGULATORY PROTEIN, FACTOR CD55, FACTOR DAF, RECEPTOR, ATTACHMENT, INFECTIVITY, REQUIRES",

author = "IG Goodfellow and AB Sioofy and RM Powell and DJ Evans",

year = "2001",

month = may,

language = "English",

volume = "75",

pages = "4918--4921",

journal = "Journal of Virology",

issn = "0022-538X",

publisher = "American Society for Microbiology",

number = "10",

}

TY - JOUR

T1 - Echoviruses bind heparan sulfate at the cell surface

AU - Goodfellow, IG

AU - Sioofy, AB

AU - Powell, RM

AU - Evans, DJ

PY - 2001/5

Y1 - 2001/5

N2 - Some echoviruses (EV) that bind decay-accelerating factor (DAF) also bind cells of human and murine origins in a DAF-independent manner. Pretreatment of cells with heparinase 1 or heparin blocks the binding of radiolabeled virus to the cell surface, and heparin prevents infection of rhabdomyosarcoma cells by certain EV, including several low-passage clinical isolates of EV 6 and some EV that do not bind DAF. These studies suggest that heparan sulfate may be of in vivo relevance as an attachment molecule for EV.

AB - Some echoviruses (EV) that bind decay-accelerating factor (DAF) also bind cells of human and murine origins in a DAF-independent manner. Pretreatment of cells with heparinase 1 or heparin blocks the binding of radiolabeled virus to the cell surface, and heparin prevents infection of rhabdomyosarcoma cells by certain EV, including several low-passage clinical isolates of EV 6 and some EV that do not bind DAF. These studies suggest that heparan sulfate may be of in vivo relevance as an attachment molecule for EV.

KW - DECAY-ACCELERATING FACTOR

KW - MOUTH-DISEASE-VIRUS

KW - RESPIRATORY SYNCYTIAL VIRUS

KW - COMPLEMENT REGULATORY PROTEIN

KW - FACTOR CD55

KW - FACTOR DAF

KW - RECEPTOR

KW - ATTACHMENT

KW - INFECTIVITY

KW - REQUIRES

M3 - Article

SN - 0022-538X

VL - 75

SP - 4918

EP - 4921

JO - Journal of Virology

JF - Journal of Virology

IS - 10

ER -

Echoviruses bind heparan sulfate at the cell surface

Abstract

Keywords

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