Echoviruses bind heparan sulfate at the cell surface

IG Goodfellow, AB Sioofy, RM Powell, DJ Evans*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

Some echoviruses (EV) that bind decay-accelerating factor (DAF) also bind cells of human and murine origins in a DAF-independent manner. Pretreatment of cells with heparinase 1 or heparin blocks the binding of radiolabeled virus to the cell surface, and heparin prevents infection of rhabdomyosarcoma cells by certain EV, including several low-passage clinical isolates of EV 6 and some EV that do not bind DAF. These studies suggest that heparan sulfate may be of in vivo relevance as an attachment molecule for EV.

Original languageEnglish
Pages (from-to)4918-4921
Number of pages4
JournalJournal of Virology
Volume75
Issue number10
Publication statusPublished - May 2001

Keywords

  • DECAY-ACCELERATING FACTOR
  • MOUTH-DISEASE-VIRUS
  • RESPIRATORY SYNCYTIAL VIRUS
  • COMPLEMENT REGULATORY PROTEIN
  • FACTOR CD55
  • FACTOR DAF
  • RECEPTOR
  • ATTACHMENT
  • INFECTIVITY
  • REQUIRES

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