Dyslexia-related loci are significantly associated with language and literacy in Chinese–English bilingual Hong Kong Chinese twins

Cheuk Yan Chung; Dora Jue  Pan; Silvia Paracchini; Wenxuan  Jiang; Hon-Cheong  So; Catherine  McBride; Urs  Maurer; Mo  Zheng; Kwong Wai  Choy

doi:10.21203/rs.3.rs-2887801/v1

Dyslexia-related loci are significantly associated with language and literacy in Chinese–English bilingual Hong Kong Chinese twins

Cheuk Yan Chung
, Dora Jue Pan
, Silvia Paracchini
, Wenxuan Jiang
, Hon-Cheong So
, Catherine McBride
, Urs Maurer
, Mo Zheng^*
, Kwong Wai Choy^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A recent genome-wide association study on dyslexia in 51,800 affected European adults and 1,087,070 controls detected 42 genome-wide significant single nucleotide variants (SNPs). The association between rs2624839 in SEMA3F and reading fluency was replicated in a Chinese cohort. This study explores the genetic overlap between Chinese and English word reading, vocabulary knowledge and spelling, and aims at replicating the association in a unique cohort of bilingual (Chinese–English) Hong Kong Chinese twins. Our result showed an almost complete genetic overlap in vocabulary knowledge (r2 = 0.995), and some genetic overlaps in word reading and spelling (r2 = 0.846, 0.687) across the languages. To investigate the region near rs2624839, we tested proxy SNPs (rs1005678, rs12632110 and rs12494414) at the population level (n = 305–308) and the within-twin level (n = 342–344 [171–172 twin pairs]). All the three SNPs showed significant associations with quantitative Chinese and English vocabulary knowledge (p

Original language	English
Journal	Human Genetics
DOIs	https://doi.org/10.21203/rs.3.rs-2887801/v1 https://doi.org/10.1007/s00439-023-02594-6
Publication status	Published - 5 Sept 2023

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Copyright © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. This work has been made available online in accordance with the Rights Retention Strategy This accepted manuscript is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The final published version of this work is available at https://doi.org/10.1007/s00439-023-02594-6.
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@article{309ca0168c7f46f68cb500f0dbe5469f,

title = "Dyslexia-related loci are significantly associated with language and literacy in Chinese{\textendash}English bilingual Hong Kong Chinese twins",

abstract = "A recent genome-wide association study on dyslexia in 51,800 affected European adults and 1,087,070 controls detected 42 genome-wide significant single nucleotide variants (SNPs). The association between rs2624839 in SEMA3F and reading fluency was replicated in a Chinese cohort. This study explores the genetic overlap between Chinese and English word reading, vocabulary knowledge and spelling, and aims at replicating the association in a unique cohort of bilingual (Chinese{\textendash}English) Hong Kong Chinese twins. Our result showed an almost complete genetic overlap in vocabulary knowledge (r2 = 0.995), and some genetic overlaps in word reading and spelling (r2 = 0.846, 0.687) across the languages. To investigate the region near rs2624839, we tested proxy SNPs (rs1005678, rs12632110 and rs12494414) at the population level (n = 305{\textendash}308) and the within-twin level (n = 342{\textendash}344 [171{\textendash}172 twin pairs]). All the three SNPs showed significant associations with quantitative Chinese and English vocabulary knowledge (p ",

author = "Chung, \{Cheuk Yan\} and Pan, \{Dora Jue\} and Silvia Paracchini and Wenxuan Jiang and Hon-Cheong So and Catherine McBride and Urs Maurer and Mo Zheng and Choy, \{Kwong Wai\}",

note = "This study was partially funded by the Research Grants Council of the Hong Kong Special Administration Region (C4054-17WF) and the Theme-based Research Scheme from the Hong Kong Special Administrative Region Research Grants Council (T44-410/21-N).",

year = "2023",

month = sep,

day = "5",

doi = "10.21203/rs.3.rs-2887801/v1",

language = "English",

journal = "Human Genetics",

issn = "0340-6717",

publisher = "Springer Science and Business Media",

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T1 - Dyslexia-related loci are significantly associated with language and literacy in Chinese–English bilingual Hong Kong Chinese twins

AU - Chung, Cheuk Yan

AU - Pan, Dora Jue

AU - Paracchini, Silvia

AU - Jiang, Wenxuan

AU - So, Hon-Cheong

AU - McBride, Catherine

AU - Maurer, Urs

AU - Zheng, Mo

AU - Choy, Kwong Wai

N1 - This study was partially funded by the Research Grants Council of the Hong Kong Special Administration Region (C4054-17WF) and the Theme-based Research Scheme from the Hong Kong Special Administrative Region Research Grants Council (T44-410/21-N).

PY - 2023/9/5

Y1 - 2023/9/5

N2 - A recent genome-wide association study on dyslexia in 51,800 affected European adults and 1,087,070 controls detected 42 genome-wide significant single nucleotide variants (SNPs). The association between rs2624839 in SEMA3F and reading fluency was replicated in a Chinese cohort. This study explores the genetic overlap between Chinese and English word reading, vocabulary knowledge and spelling, and aims at replicating the association in a unique cohort of bilingual (Chinese–English) Hong Kong Chinese twins. Our result showed an almost complete genetic overlap in vocabulary knowledge (r2 = 0.995), and some genetic overlaps in word reading and spelling (r2 = 0.846, 0.687) across the languages. To investigate the region near rs2624839, we tested proxy SNPs (rs1005678, rs12632110 and rs12494414) at the population level (n = 305–308) and the within-twin level (n = 342–344 [171–172 twin pairs]). All the three SNPs showed significant associations with quantitative Chinese and English vocabulary knowledge (p

AB - A recent genome-wide association study on dyslexia in 51,800 affected European adults and 1,087,070 controls detected 42 genome-wide significant single nucleotide variants (SNPs). The association between rs2624839 in SEMA3F and reading fluency was replicated in a Chinese cohort. This study explores the genetic overlap between Chinese and English word reading, vocabulary knowledge and spelling, and aims at replicating the association in a unique cohort of bilingual (Chinese–English) Hong Kong Chinese twins. Our result showed an almost complete genetic overlap in vocabulary knowledge (r2 = 0.995), and some genetic overlaps in word reading and spelling (r2 = 0.846, 0.687) across the languages. To investigate the region near rs2624839, we tested proxy SNPs (rs1005678, rs12632110 and rs12494414) at the population level (n = 305–308) and the within-twin level (n = 342–344 [171–172 twin pairs]). All the three SNPs showed significant associations with quantitative Chinese and English vocabulary knowledge (p

U2 - 10.21203/rs.3.rs-2887801/v1

DO - 10.21203/rs.3.rs-2887801/v1

M3 - Article

SN - 0340-6717

JO - Human Genetics

JF - Human Genetics

ER -

Dyslexia-related loci are significantly associated with language and literacy in Chinese–English bilingual Hong Kong Chinese twins

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