Do HPV-negative cervical carcinomas exist?--revisited

Charles Simon Herrington

doi:10.1002/(SICI)1096-9896(199909)189:1<1::AID-PATH432>3.0.CO;2-P

Do HPV-negative cervical carcinomas exist?--revisited

Charles Simon Herrington

School of Medicine

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

There has been considerable debate regarding the existence of HPV-negative cervical carcinoma. In this issue of the journal, using well-controlled methodology, Walboomers et al. demonstrate that HPV DNA is present in almost all invasive carcinomas in a large multinational study. This indicates that HPV-negative carcinoma is extremely uncommon, if it exists at all. It also implies that HPV testing, if optimally applied, is capable of a sensitivity approaching 100 per cent. This has significant implications for cervical screening. Copyright (C) 1999 John Wiley & Sons, Ltd.

Original language	English
Pages (from-to)	1-3
Number of pages	3
Journal	Journal of Pathology
Volume	189
Issue number	1
DOIs	https://doi.org/10.1002/(SICI)1096-9896(199909)189:1<1::AID-PATH432>3.0.CO;2-P
Publication status	Published - Sept 1999

Keywords

papillomavirus
carcinoma
cervix
testing
HUMAN PAPILLOMAVIRUS INFECTION
CELL-LINES
HIGH-RISK
P53
PCR
MUTATIONS
GENOTYPES
CANCER
GENE
INTEGRATION

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/(SICI)1096-9896(199909)189:1<1::AID-PATH432>3.0.CO;2-P

Cite this

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title = "Do HPV-negative cervical carcinomas exist?--revisited",

abstract = "There has been considerable debate regarding the existence of HPV-negative cervical carcinoma. In this issue of the journal, using well-controlled methodology, Walboomers et al. demonstrate that HPV DNA is present in almost all invasive carcinomas in a large multinational study. This indicates that HPV-negative carcinoma is extremely uncommon, if it exists at all. It also implies that HPV testing, if optimally applied, is capable of a sensitivity approaching 100 per cent. This has significant implications for cervical screening. Copyright (C) 1999 John Wiley & Sons, Ltd.",

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AB - There has been considerable debate regarding the existence of HPV-negative cervical carcinoma. In this issue of the journal, using well-controlled methodology, Walboomers et al. demonstrate that HPV DNA is present in almost all invasive carcinomas in a large multinational study. This indicates that HPV-negative carcinoma is extremely uncommon, if it exists at all. It also implies that HPV testing, if optimally applied, is capable of a sensitivity approaching 100 per cent. This has significant implications for cervical screening. Copyright (C) 1999 John Wiley & Sons, Ltd.

KW - papillomavirus

KW - carcinoma

KW - cervix

KW - testing

KW - HUMAN PAPILLOMAVIRUS INFECTION

KW - CELL-LINES

KW - HIGH-RISK

KW - P53

KW - PCR

KW - MUTATIONS

KW - GENOTYPES

KW - CANCER

KW - GENE

KW - INTEGRATION

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SP - 1

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JF - Journal of Pathology

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Do HPV-negative cervical carcinomas exist?--revisited

Abstract

Keywords

UN SDGs

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