Dissolving biomolecules and modifying biomedical implants with supercritical carbon dioxide

PB Webb; PC Marr; AJ Parsons; HS Gidda; SM Howdle

doi:10.1351/pac200072071347

Dissolving biomolecules and modifying biomedical implants with supercritical carbon dioxide

PB Webb, PC Marr, AJ Parsons, HS Gidda, SM Howdle^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

We describe two methodologies for dissolving ionic/polar species in scCO(2). Both lead to a broadening of the range of applications for scCO(2). Fluorinated surfactants may be used to prepare water in carbon dioxide microemulsions to allow solubilization of ionic and biological species. We outline also the preparation of scCO(2) soluble metal precursors that can be impregnated efficiently into polymeric substrates. Further processing by heat or UV light leads to metallic particles distributed throughout a polymer substrate. The clean synthesis of such composites can be applied to the development of improved medical implants.

Original language	English
Pages (from-to)	1347-1355
Number of pages	9
Journal	Pure and Applied Chemistry
Volume	72
Issue number	7
DOIs	https://doi.org/10.1351/pac200072071347
Publication status	Published - Jul 2000
Event	Workshop on Sustainable Chemistry - VENICE, Italy Duration: 15 Oct 1998 → 17 Oct 1998

Keywords

MICROEMULSIONS
FLUIDS
WATER
IMPREGNATION
ENVIRONMENT
EXTRACTION
CHEMISTRY
CO2

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10.1351/pac200072071347

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title = "Dissolving biomolecules and modifying biomedical implants with supercritical carbon dioxide",

abstract = "We describe two methodologies for dissolving ionic/polar species in scCO(2). Both lead to a broadening of the range of applications for scCO(2). Fluorinated surfactants may be used to prepare water in carbon dioxide microemulsions to allow solubilization of ionic and biological species. We outline also the preparation of scCO(2) soluble metal precursors that can be impregnated efficiently into polymeric substrates. Further processing by heat or UV light leads to metallic particles distributed throughout a polymer substrate. The clean synthesis of such composites can be applied to the development of improved medical implants.",

keywords = "MICROEMULSIONS, FLUIDS, WATER, IMPREGNATION, ENVIRONMENT, EXTRACTION, CHEMISTRY, CO2",

author = "PB Webb and PC Marr and AJ Parsons and HS Gidda and SM Howdle",

year = "2000",

month = jul,

doi = "10.1351/pac200072071347",

language = "English",

volume = "72",

pages = "1347--1355",

journal = "Pure and Applied Chemistry",

issn = "0033-4545",

publisher = "IUPAC Secretariat",

number = "7",

note = "Workshop on Sustainable Chemistry ; Conference date: 15-10-1998 Through 17-10-1998",

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TY - JOUR

T1 - Dissolving biomolecules and modifying biomedical implants with supercritical carbon dioxide

AU - Webb, PB

AU - Marr, PC

AU - Parsons, AJ

AU - Gidda, HS

AU - Howdle, SM

PY - 2000/7

Y1 - 2000/7

N2 - We describe two methodologies for dissolving ionic/polar species in scCO(2). Both lead to a broadening of the range of applications for scCO(2). Fluorinated surfactants may be used to prepare water in carbon dioxide microemulsions to allow solubilization of ionic and biological species. We outline also the preparation of scCO(2) soluble metal precursors that can be impregnated efficiently into polymeric substrates. Further processing by heat or UV light leads to metallic particles distributed throughout a polymer substrate. The clean synthesis of such composites can be applied to the development of improved medical implants.

AB - We describe two methodologies for dissolving ionic/polar species in scCO(2). Both lead to a broadening of the range of applications for scCO(2). Fluorinated surfactants may be used to prepare water in carbon dioxide microemulsions to allow solubilization of ionic and biological species. We outline also the preparation of scCO(2) soluble metal precursors that can be impregnated efficiently into polymeric substrates. Further processing by heat or UV light leads to metallic particles distributed throughout a polymer substrate. The clean synthesis of such composites can be applied to the development of improved medical implants.

KW - MICROEMULSIONS

KW - FLUIDS

KW - WATER

KW - IMPREGNATION

KW - ENVIRONMENT

KW - EXTRACTION

KW - CHEMISTRY

KW - CO2

U2 - 10.1351/pac200072071347

DO - 10.1351/pac200072071347

M3 - Article

SN - 0033-4545

VL - 72

SP - 1347

EP - 1355

JO - Pure and Applied Chemistry

JF - Pure and Applied Chemistry

IS - 7

T2 - Workshop on Sustainable Chemistry

Y2 - 15 October 1998 through 17 October 1998

ER -

Dissolving biomolecules and modifying biomedical implants with supercritical carbon dioxide

Abstract

Keywords

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