Direct synthesis of amides by the dehydrogenative coupling of amines with alcohols or esters: manganese pincer complex as catalyst

Amit Kumar; Noel A Espinoza-Jalapa; G Leitus; Yael Diskin-Posner; Liat Avram; David Milstein

doi:10.1002/anie.201709180

Direct synthesis of amides by the dehydrogenative coupling of amines with alcohols or esters: manganese pincer complex as catalyst

Amit Kumar, Noel A Espinoza-Jalapa, G Leitus, Yael Diskin-Posner, Liat Avram, David Milstein

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The first example of base‐metal‐catalysed synthesis of amides from the coupling of primary amines with either alcohols or esters is reported. The reactions are catalysed by a new manganese pincer complex and generate hydrogen gas as the sole byproduct, thus making the overall process atom‐economical and sustainable.

Original language	English
Pages (from-to)	14992-14996
Journal	Angewandte Chemie International Edition
Volume	56
Issue number	47
Early online date	20 Oct 2017
DOIs	https://doi.org/10.1002/anie.201709180
Publication status	Published - 15 Nov 2017

Keywords

Amides
Amines
Ligand design
Manganese
Structure elucidation

Access to Document

10.1002/anie.201709180

Cite this

@article{dd1cf695d8b2453a9e030b956acd202e,

title = "Direct synthesis of amides by the dehydrogenative coupling of amines with alcohols or esters: manganese pincer complex as catalyst",

abstract = "The first example of base‐metal‐catalysed synthesis of amides from the coupling of primary amines with either alcohols or esters is reported. The reactions are catalysed by a new manganese pincer complex and generate hydrogen gas as the sole byproduct, thus making the overall process atom‐economical and sustainable.",

keywords = "Amides, Amines, Ligand design, Manganese, Structure elucidation",

author = "Amit Kumar and Espinoza-Jalapa, \{Noel A\} and G Leitus and Yael Diskin-Posner and Liat Avram and David Milstein",

note = "This research was supported by the European Research Council (ERC AdG 692775). D.M. holds the Israel Matz Professorial Chair of Organic Chemistry. A.K. is thankful to the Israel Planning and Budgeting Commission (PBC) for a fellowship. N.A.E.‐J. thanks Mr. Armando Jinich for a postdoctoral fellowship.",

year = "2017",

month = nov,

day = "15",

doi = "10.1002/anie.201709180",

language = "English",

volume = "56",

pages = "14992--14996",

journal = "Angewandte Chemie International Edition",

issn = "1433-7851",

publisher = "John Wiley \& Sons, Ltd",

number = "47",

}

TY - JOUR

T1 - Direct synthesis of amides by the dehydrogenative coupling of amines with alcohols or esters

T2 - manganese pincer complex as catalyst

AU - Kumar, Amit

AU - Espinoza-Jalapa, Noel A

AU - Leitus, G

AU - Diskin-Posner, Yael

AU - Avram, Liat

AU - Milstein, David

N1 - This research was supported by the European Research Council (ERC AdG 692775). D.M. holds the Israel Matz Professorial Chair of Organic Chemistry. A.K. is thankful to the Israel Planning and Budgeting Commission (PBC) for a fellowship. N.A.E.‐J. thanks Mr. Armando Jinich for a postdoctoral fellowship.

PY - 2017/11/15

Y1 - 2017/11/15

N2 - The first example of base‐metal‐catalysed synthesis of amides from the coupling of primary amines with either alcohols or esters is reported. The reactions are catalysed by a new manganese pincer complex and generate hydrogen gas as the sole byproduct, thus making the overall process atom‐economical and sustainable.

AB - The first example of base‐metal‐catalysed synthesis of amides from the coupling of primary amines with either alcohols or esters is reported. The reactions are catalysed by a new manganese pincer complex and generate hydrogen gas as the sole byproduct, thus making the overall process atom‐economical and sustainable.

KW - Amides

KW - Amines

KW - Ligand design

KW - Manganese

KW - Structure elucidation

UR - https://onlinelibrary.wiley.com/doi/10.1002/anie.201709180

UR - https://www.scopus.com/pages/publications/85031746903

U2 - 10.1002/anie.201709180

DO - 10.1002/anie.201709180

M3 - Article

SN - 1433-7851

VL - 56

SP - 14992

EP - 14996

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 47

ER -

Direct synthesis of amides by the dehydrogenative coupling of amines with alcohols or esters: manganese pincer complex as catalyst

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Amit Kumar

Cite this

Direct synthesis of amides by the dehydrogenative coupling of amines with alcohols or esters: manganese pincer complex as catalyst

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Profiles

Amit Kumar

Cite this