Direct synthesis of amides by the dehydrogenative coupling of amines with alcohols or esters: manganese pincer complex as catalyst

Amit Kumar, Noel A Espinoza-Jalapa, G Leitus, Yael Diskin-Posner, Liat Avram, David Milstein

Research output: Contribution to journalArticlepeer-review

137 Citations (Scopus)

Abstract

The first example of base‐metal‐catalysed synthesis of amides from the coupling of primary amines with either alcohols or esters is reported. The reactions are catalysed by a new manganese pincer complex and generate hydrogen gas as the sole byproduct, thus making the overall process atom‐economical and sustainable.
Original languageEnglish
Pages (from-to)14992-14996
JournalAngewandte Chemie International Edition
Volume56
Issue number47
Early online date20 Oct 2017
DOIs
Publication statusPublished - 15 Nov 2017

Keywords

  • Amides
  • Amines
  • Ligand design
  • Manganese
  • Structure elucidation

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