Direct synthesis of amides by the dehydrogenative coupling of amines with alcohols or esters: manganese pincer complex as catalyst

Amit Kumar, Noel A Espinoza-Jalapa, G Leitus, Yael Diskin-Posner, Liat Avram, David Milstein

Research output: Contribution to journalArticlepeer-review

Abstract

The first example of base‐metal‐catalysed synthesis of amides from the coupling of primary amines with either alcohols or esters is reported. The reactions are catalysed by a new manganese pincer complex and generate hydrogen gas as the sole byproduct, thus making the overall process atom‐economical and sustainable.
Original languageEnglish
Pages (from-to)14992-14996
JournalAngewandte Chemie International Edition
Volume56
Issue number47
Early online date20 Oct 2017
DOIs
Publication statusPublished - 15 Nov 2017

Keywords

  • Amides
  • Amines
  • Ligand design
  • Manganese
  • Structure elucidation

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