Abstract
The development of neoplasia is associated with abnormalities of cell cycle control and apoptosis. In this study, a panel of cyclin-dependent kinase inhibitors (CDKIs) and apoptosis-related proteins (p16, p21, p53, Bc12 and hsp27) was analysed by immunohistochernistry in 91 glandular cervical lesions. A significant increase in p21 and p53 expression occurred from normal cervix (n = 11) through endometriosis/tubo-endometrioid metaplasia (TEM) (n = 19) and cervical glandular intraepithelial neoplasia (CGIN)/adenocarcinoma in situ (AIS) (n = 33) to invasive adenocarcinoma (n = 28). p16 showed diffuse strong expression in CGIN/AIS and invasive adenocarcinoma compared with focal expression in some TEW endometriosis lesions and no expression in normal cervix. Bc12 was highly expressed in TEM/endometriosis compared with CGIN/AIS and adenocarcinoma. p16 immunostaining discriminated accurately between neoplastic and non-neoplastic cervical lesions, provided that diffuse strong positivity was present. Similarly, diffuse expression of Bc12 distinguished endometriosis/TEM from CGIN/AIS. These data demonstrate that analysis of CDKIs and apoptosis-related proteins provides useful information in the diagnostic assessment of glandular lesions of the cervix. (C) 2007 Elsevier Ltd. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 2011-2018 |
| Number of pages | 8 |
| Journal | European Journal of Cancer |
| Volume | 43 |
| DOIs | |
| Publication status | Published - Sept 2007 |
Keywords
- cervix
- glandular lesions
- neoplasia
- metaplasia
- cyclin-dependent kinase inhibitors
- apoptosis
- CERVICAL INTRAEPITHELIAL NEOPLASIA
- SQUAMOUS-CELL CARCINOMA
- CDK INHIBITORS
- UTERINE CERVIX
- HUMAN CANCER
- ADENOCARCINOMA
- P16(INK4A)
- BCL-2
- P21
- P16
