Differential expression of cyclin-dependent kinase inhibitors and apoptosis-related proteins in endocervical lesions.

AA El-Ghobashy, AM Shabaan, J Innes, W Prime, Charles Simon Herrington

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

The development of neoplasia is associated with abnormalities of cell cycle control and apoptosis. In this study, a panel of cyclin-dependent kinase inhibitors (CDKIs) and apoptosis-related proteins (p16, p21, p53, Bc12 and hsp27) was analysed by immunohistochernistry in 91 glandular cervical lesions. A significant increase in p21 and p53 expression occurred from normal cervix (n = 11) through endometriosis/tubo-endometrioid metaplasia (TEM) (n = 19) and cervical glandular intraepithelial neoplasia (CGIN)/adenocarcinoma in situ (AIS) (n = 33) to invasive adenocarcinoma (n = 28). p16 showed diffuse strong expression in CGIN/AIS and invasive adenocarcinoma compared with focal expression in some TEW endometriosis lesions and no expression in normal cervix. Bc12 was highly expressed in TEM/endometriosis compared with CGIN/AIS and adenocarcinoma. p16 immunostaining discriminated accurately between neoplastic and non-neoplastic cervical lesions, provided that diffuse strong positivity was present. Similarly, diffuse expression of Bc12 distinguished endometriosis/TEM from CGIN/AIS. These data demonstrate that analysis of CDKIs and apoptosis-related proteins provides useful information in the diagnostic assessment of glandular lesions of the cervix. (C) 2007 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)2011-2018
Number of pages8
JournalEuropean Journal of Cancer
Volume43
DOIs
Publication statusPublished - Sept 2007

Keywords

  • cervix
  • glandular lesions
  • neoplasia
  • metaplasia
  • cyclin-dependent kinase inhibitors
  • apoptosis
  • CERVICAL INTRAEPITHELIAL NEOPLASIA
  • SQUAMOUS-CELL CARCINOMA
  • CDK INHIBITORS
  • UTERINE CERVIX
  • HUMAN CANCER
  • ADENOCARCINOMA
  • P16(INK4A)
  • BCL-2
  • P21
  • P16

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