Different patterns of supra­molecular aggregation in three amides containing N-(benzo[d]thia­zol­yl) substituents

Ninganayaka Mahesha, Hemmige S. Yathirajan, Holalagudu A. Nagma Banu, Balakrishna Kalluraya, Sabine Foro, Christopher Glidewell

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Crystal structures are reported for three amides containing N-benzo[d]thia­zole substituents. In N-(benzo[d]thia­zol-6-yl)-3-bromo­benzamide, C14H9BrN2OS, where the two ring systems are nearly parallel to one another [dihedral angle = 5.8 (2)°], the mol­ecules are linked by N—H⋯O and C—H⋯N hydrogen bonds to form ribbons of R33(19) rings, which are linked into sheets by short Br⋯Br inter­actions [3.5812 (6) Å]. N-(6-Meth­oxy­benzo[d]thia­zol-2-yl)-2-nitro­benzamide, C15H11N3O4S, crystallizes with Z′ = 2 in space group Pna21: the dihedral angles between the ring systems [46.43 (15) and 66.35 (13)°] are significantly different in the independent mol­ecules and a combination of two N—H⋯N and five C—H⋯O hydrogen bonds links the mol­ecules into a three-dimensional network. The mol­ecules of 5-cyclo­propyl-N-(6-meth­oxy­ben­zo[d]thia­zol-2-yl)­isoxazole-3-carboxamide, C15H13N3O3S, exhibit two forms of disorder, in the meth­oxy group and in the cyclo­propyl­isoxazole unit; symmetry-related pairs of mol­ecules are linked into dimers by pairwise N—H⋯N hydrogen bonds. Comparisons are made with the structures of some related compounds.
Original languageEnglish
Pages (from-to)504-511
Number of pages8
JournalActa Crystallographica Section E Crystallographic Communications
Issue numberPart 5
Early online date9 Apr 2021
Publication statusPublished - May 2021


  • Benzo[d]thia­zoles
  • Crystal structure
  • Disorder
  • Halogen bonding
  • Heterocyclic compounds
  • Hydrogen bonding
  • Mol­ecular conformation


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