Development of versatile and silver-free protocols for gold(I) catalysis

Sylvain Gaillard, Johann Bosson, Ruben S. Ramon, Pierrick Nun, Alexandra M. Z. Slawin, Steven P. Nolan

Research output: Contribution to journalArticlepeer-review

165 Citations (Scopus)

Abstract

The use of a versatile N-heterocyclic carbene (NHC) gold(I) hydroxide precatalyst, [Au(OH)(IPr)], (IPr = N,N'-bis(2,6-diisopropylphenyl)-imidazol-2-ylidene) permits the in situ generation of the [Au(IPr)](+) ion by simple addition of a Bronsted acid. This cationic entity is believed to be the active species in numerous catalytic reactions. H-1 NMR studies in several solvent media of the in situ generation of this [Au(IPr)](+) ion also reveal the formation of a dinuclear gold hydroxide intermediate [{Au(IPr)}(2)(mu-OH)], which is fully characterized and was tested in gold(I) catalysis.

Original languageEnglish
Pages (from-to)13729-13740
Number of pages12
JournalChemistry - A European Journal
Volume16
Issue number46
Early online date13 Oct 2010
DOIs
Publication statusPublished - 10 Dec 2010

Keywords

  • gold
  • homogeneous catalysis
  • N-heterocyclic carbenes
  • Gold(I)-Catalyzed Intramolecular Hydroamination
  • N-Heterocyclic Carbenes
  • Highly Efficient
  • Propargylic Acetates
  • Inorganic-Chemistry
  • Platinum Catalysis
  • Ene Reaction
  • C-C
  • Complexes
  • Alkynes

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