Development of a sustainable catalytic ester amidation process

Nicola Caldwell, Craig Jamieson, Iain Simpson, Allan J. B. Watson

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


We describe the development of a sustainable ester amidation process. Base and solvent screening, combined with the application of Design of Experiments methodology was employed to identify an optimized set of reaction conditions using a sustainable protocol. Utilizing these optimized conditions, treatment of a range of ester derivatives with amino alcohols in the presence of a catalytic quantity of potassium phosphate deploying iso-propanol as solvent results in the highly efficient generation of a range of amido-alcohol derivatives in good to excellent yield, accompanied with excellent reaction mass efficiency (RME).
Original languageEnglish
Pages (from-to)1339-1344
Number of pages6
JournalACS Sustainable Chemistry & Engineering
Issue number10
Publication statusPublished - 7 Oct 2013


  • sustainable ester amidation
  • amino alcohol
  • reaction mass efficiency
  • potassium phosphate


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