Detection of Antibodies to Spotted Fever Group Rickettsiae and Arboviral Coinfections in Febrile Individuals in 2014-2015 in Southern Coastal Ecuador

Lorne Farovitch, Rachel Sippy, Efraín Beltrán-Ayala, Timothy P Endy, Anna M Stewart-Ibarra, Brian F Leydet

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Tick-borne diseases (TBDs) are a growing public health threat and are increasingly identified as the cause of undifferentiated febrile illness. There is a significant gap in our understanding of ticks and their associated pathogens in Ecuador. An arboviral surveillance study allowed us to explore potential exposure to TBDs in febrile subjects. We tested plasma samples from 222 febrile subjects for spotted fever group rickettsial (SFGR) antibodies from southern coastal Ecuador in 2014-2015 via ELISA. Fifty-five (25%) subjects had evidence of anti-SFRG IgG or IgM antibodies. Although attempts to detect Rickettsia species in plasma by polymerase chain reaction were unsuccessful, these preliminary data suggest the possibility of endemic SFGR transmission in Ecuador. To better understand the burden and entomological risk for TBDs in Ecuador, future studies should expand TBD surveillance in humans, document common human-biting ticks, and measure pathogen carriage rates in questing ticks.

Original languageEnglish
Pages (from-to)1087-1090
Number of pages4
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume101
Issue number5
DOIs
Publication statusPublished - Nov 2019

Keywords

  • Adolescent
  • Adult
  • Antibodies, Bacterial/blood
  • Arbovirus Infections/epidemiology
  • Child
  • Coinfection/epidemiology
  • Ecuador/epidemiology
  • Female
  • Fever
  • Humans
  • Immunoglobulin M/blood
  • Male
  • Middle Aged
  • Retrospective Studies
  • Spotted Fever Group Rickettsiosis/epidemiology
  • Young Adult

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